Small Molecule Library Synthesis Using Segmented Flow
AbstractFlow chemistry has gained considerable recognition as a simple, efficient, and safe technology for the synthesis of many types of organic and inorganic molecules ranging in scope from large complex natural products to silicon nanoparticles. In this paper we describe a method that adapts flow chemistry to the synthesis of libraries of compounds using a fluorous immiscible solvent as a spacer between reactions. The methodology was validated in the synthesis of two small heterocycle containing libraries. The reactions were performed on a 0.2 mmol scale, enabling tens of milligrams of material to be generated in a single 200 mL reaction plug. The methodology allowed library synthesis in half the time of conventional microwave synthesis while maintaining similar yields. The ability to perform multiple, potentially unrelated reactions in a single run is ideal for making small quantities of many different compounds quickly and efficiently.
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Thompson, C.M.; Poole, J.L.; Cross, J.L.; Akritopoulou-Zanze, I.; Djuric, S.W. Small Molecule Library Synthesis Using Segmented Flow. Molecules 2011, 16, 9161-9177.
Thompson CM, Poole JL, Cross JL, Akritopoulou-Zanze I, Djuric SW. Small Molecule Library Synthesis Using Segmented Flow. Molecules. 2011; 16(11):9161-9177.Chicago/Turabian Style
Thompson, Christina M.; Poole, Jennifer L.; Cross, Jeffrey L.; Akritopoulou-Zanze, Irini; Djuric, Stevan W. 2011. "Small Molecule Library Synthesis Using Segmented Flow." Molecules 16, no. 11: 9161-9177.