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Comment published on 14 March 2013, see Molecules 2013, 18(3), 3442-3444.

Retraction published on 27 March 2013, see Molecules 2013, 18(4), 3839-3840.

Open AccessArticle
Molecules 2012, 17(12), 13937-13947; doi:10.3390/molecules171213937

Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia
Dental Research & Training Unit and Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia
Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (LIMBR), School of Medicine (SoM), Faculty of Health, Institute for Frontier Materials (IFM), Deakin University, Waurn Ponds, Victoria 3217, Australia
Author to whom correspondence should be addressed.
Received: 9 November 2012 / Revised: 15 November 2012 / Accepted: 19 November 2012 / Published: 23 November 2012
(This article belongs to the Section Natural Products)
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The aim of the present study was to evaluate the hepatoprotective activity of lantadene A against acetaminophen-induced liver toxicity in mice was studied. Activity was measured by monitoring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin, along with histo-pathological analysis. Silymarin was used as positive control. A bimodal pattern of behavioural toxicity was exhibited by the lantadene A-treated group at the beginning of the treatment. However, treatment with lantadene A and silymarin resulted in an increase in the liver weight compared with the acetaminophen treated group. The results of the acetaminophen-induced liver toxicity experiments showed that mice treated with lantadene A (500 mg/kg) showed a significant decrease in the activity of ALT, AST and ALP and the level of bilirubin, which were all elevated in the acetaminophen treated group (p < 0.05). Histological studies supported the biochemical findings and a maximum improvement in the histoarchitecture was seen. The lantadene A-treated group showed remarkable protective effects against histopathological alterations, with comparable results to the silymarin treated group. The current study confirmed the hepatoprotective effects of lantadene A against the model hepatotoxicant acetaminophen, which is likely related to its potent antioxidative activity.
Keywords: acetaminophen; hepatoprotective; antioxidant activity; lantadene A; triterpenes  acetaminophen; hepatoprotective; antioxidant activity; lantadene A; triterpenes 

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Grace-Lynn, C.; Chen, Y.; Latha, L.Y.; Kanwar, J.R.; Jothy, S.L.; Vijayarathna, S.; Sasidharan, S. Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage. Molecules 2012, 17, 13937-13947.

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