Evaluation of the Antiproliferative Activity of the Leaves from Arctium lappa by a Bioassay-Guided Fractionation
Abstract
:1. Introduction
2. Results and Discussion
2.1. Extraction Yield
2.2. Antiproliferative Activity
Subfractions | CC50 (µg/mL) ( x ± sd) |
---|---|
1 | >100 |
2 | >100 |
3 | 52 ± 15.5 |
4 | 64.5 ± 19.09 |
5 | 47 ± 26.9 |
6 | 66 ± 7.07 |
7 | >100 |
8 | >100 |
9 | >100 |
10 | >100 |
11 | 78 ± 4.2 |
12 | 23.8 ± 2.9 |
13 | 25.1 ± 4.3 |
14 | 25 ± 0.0 |
15 | 29.3 ± 3.2 |
16 | 29.9 ± 5.3 |
17 | 59.1 ± 12.9 |
18 | 73.5 ± 2.1 |
19 | 74 ± 2.8 |
20 | 74 ± 0.0 |
21 | >100 |
22 | >100 |
3. Experimental
3.1. General
3.2. Plant Material
3.3. Extraction, Isolation, and Identification of Compounds
3.4. Cell Culture
3.5. Antiproliferative Activity Assay
3.6. Statistical Analysis
4. Conclusions
Supplementary Materials
Acknowledgements
- Sample Availability: Samples of the compounds 1 and 2 are available from the authors.
References and Notes
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Share and Cite
Machado, F.B.; Yamamoto, R.E.; Zanoli, K.; Nocchi, S.R.; Novello, C.R.; Schuquel, I.T.A.; Sakuragui, C.M.; Luftmann, H.; Ueda-Nakamura, T.; Nakamura, C.V.; et al. Evaluation of the Antiproliferative Activity of the Leaves from Arctium lappa by a Bioassay-Guided Fractionation. Molecules 2012, 17, 1852-1859. https://doi.org/10.3390/molecules17021852
Machado FB, Yamamoto RE, Zanoli K, Nocchi SR, Novello CR, Schuquel ITA, Sakuragui CM, Luftmann H, Ueda-Nakamura T, Nakamura CV, et al. Evaluation of the Antiproliferative Activity of the Leaves from Arctium lappa by a Bioassay-Guided Fractionation. Molecules. 2012; 17(2):1852-1859. https://doi.org/10.3390/molecules17021852
Chicago/Turabian StyleMachado, Fabio Bahls, Rafael Eidi Yamamoto, Karine Zanoli, Samara Requena Nocchi, Cláudio Roberto Novello, Ivânia Teresinha Albrecht Schuquel, Cássia Mônica Sakuragui, Heinrich Luftmann, Tânia Ueda-Nakamura, Celso Vataru Nakamura, and et al. 2012. "Evaluation of the Antiproliferative Activity of the Leaves from Arctium lappa by a Bioassay-Guided Fractionation" Molecules 17, no. 2: 1852-1859. https://doi.org/10.3390/molecules17021852