Mechanistic Study of the Spiroindolones: A New Class of Antimalarials
AbstractDuring the synthesis of the new antimalarial drug candidate NITD609, a high degree of diastereoselectivity was observed in the Pictet-Spengler reaction. By isolating both the 4E and 4Z imine intermediates, a systematic mechanistic study of the reaction under both kinetic and thermodynamic conditions was conducted. This study provides insight into the source of the diastereoselectivity for this important class of compounds.
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Zou, B.; Yap, P.; Sonntag, L.-S.; Leong, S.Y.; Yeung, B.K.S.; Keller, T.H. Mechanistic Study of the Spiroindolones: A New Class of Antimalarials. Molecules 2012, 17, 10131-10141.
Zou B, Yap P, Sonntag L-S, Leong SY, Yeung BKS, Keller TH. Mechanistic Study of the Spiroindolones: A New Class of Antimalarials. Molecules. 2012; 17(9):10131-10141.Chicago/Turabian Style
Zou, Bin; Yap, Peiling; Sonntag, Louis-Sebastian; Leong, Seh Yong; Yeung, Bryan K. S.; Keller, Thomas H. 2012. "Mechanistic Study of the Spiroindolones: A New Class of Antimalarials." Molecules 17, no. 9: 10131-10141.