Ent-Abietanoids Isolated from Isodon serra
AbstractFour new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3α,14β)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound 1 showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50 = 1.8 μM) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480). View Full-Text
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Wan, J.; Jiang, H.-Y.; Tang, J.-W.; Li, X.-R.; Du, X.; Li, Y.; Sun, H.-D.; Pu, J.-X. Ent-Abietanoids Isolated from Isodon serra. Molecules 2017, 22, 309.
Wan J, Jiang H-Y, Tang J-W, Li X-R, Du X, Li Y, Sun H-D, Pu J-X. Ent-Abietanoids Isolated from Isodon serra. Molecules. 2017; 22(2):309.Chicago/Turabian Style
Wan, Jun; Jiang, Hua-Yi; Tang, Jian-Wei; Li, Xing-Ren; Du, Xue; Li, Yan; Sun, Han-Dong; Pu, Jian-Xin. 2017. "Ent-Abietanoids Isolated from Isodon serra." Molecules 22, no. 2: 309.
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