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Molecules 2017, 22(8), 1341; doi:10.3390/molecules22081341

A Pectic Polysaccharide from Sijunzi Decoction Promotes the Antioxidant Defenses of SW480 Cells

1
Laboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
2
Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
3
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
4
Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China
5
Key Laboratory of Crop Ecophysiology and Farming System in Southwest China, Ministry of Agriculture, College of Agronomy, Sichuan Agricultural University, Chengdu 611130, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 28 July 2017 / Revised: 9 August 2017 / Accepted: 11 August 2017 / Published: 12 August 2017
(This article belongs to the Special Issue Advances in Natural Polysaccharides Research)
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Abstract

Sijunzi Decoction (SJZD) is a formula used for the treatment of spleen deficiency and gastrointestinal diseases in Traditional Chinese Medicine. Polysaccharides are reported to be the main components of SJZD responsible for its bio-functions. However, highly purified and clearly characterized polysaccharides from SJZD are not well described. Here we obtained a purified polysaccharide (SJZDP-II-I) from SJZD using ion exchange chromatography and gel filtration. Structure analysis by FT-IR and NMR identified SJZDP-II-I as a typical pectic polysaccharide with homogalacturonan and rhamnogalacturonan type I regions and arabinogalactan type I and II as side chains. In vitro studies indicated that SJZDP-II-I treatment could significantly enhance the total antioxidant capacity of SW480 cells, resulting from the promoted expressions of antioxidant enzymes and their master regulator PGC-1α, which would be valuable for further research and applications. View Full-Text
Keywords: Sijunzi Decoction; SJZD; pectic polysaccharide; oxidative stress; antioxidant defense Sijunzi Decoction; SJZD; pectic polysaccharide; oxidative stress; antioxidant defense
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MDPI and ACS Style

Huang, C.; Zhu, Z.; Cao, X.; Chen, X.; Fu, Y.; Chen, Z.; Li, L.; Song, X.; Jia, R.; Yin, Z.; Ye, G.; Feng, B.; Zou, Y. A Pectic Polysaccharide from Sijunzi Decoction Promotes the Antioxidant Defenses of SW480 Cells. Molecules 2017, 22, 1341.

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