Next Issue

E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Table of Contents

Molecules, Volume 5, Issue 1 (January 2000), Pages 1-98, Articles M127-M133

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Readerexternal link to open them.
View options order results:
result details:
Displaying articles 1-16
Export citation of selected articles as:

Editorial

Jump to: Research, Review, Other

Open AccessEditorial Molecules, MolBank and ECSOC-4
Molecules 2000, 5(1), 1-3; doi:10.3390/50100001
Received: 18 January 2000 / Published: 31 January 2000
Cited by 3 | PDF Full-text (17 KB)

Research

Jump to: Editorial, Review, Other

Open AccessArticle General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones
Molecules 2000, 5(1), 19-32; doi:10.3390/50100019
Received: 7 December 1999 / Accepted: 31 December 1999 / Published: 21 January 2000
Cited by 28 | PDF Full-text (65 KB)
Abstract Reaction of 4-hydroxy-6-methyl-2-pyrone (1a) as well as 4-hydroxy-6-methyl-2(1H)-pyridones (1b-d) with arylmethylene malononitriles or arylmethylene methyl cyanoacetates (2a-h) leads to the formation of the very stable 5,6-fused bicyclic 2-amino-4Hpyran derivatives 3a-3af. Full article
Open AccessArticle On the Need for Multiple Lists of Chemical Information
Molecules 2000, 5(1), 33-36; doi:10.3390/50100033
Received: 14 January 2000 / Accepted: 14 January 2000 / Published: 21 January 2000
PDF Full-text (18 KB)
Abstract Cambridge University Department of Chemistry has a list of University Chemistry Departments and Chemistry-related journals around the world: ChemSites (http://www.ch.cam.ac.uk/ChemSitesIndex.html). This article describes what makes it distinct from other lists, and justifies the existence of more than one such list. Full article
Open AccessArticle Acid-Base Initiated Cyclization and Retrocyclization Reactions of Ethyl 2-(3-Acylselenoureido)benzoates, -thiophene-3-carboxylates and the Corresponding 2-(3-Acylisoselenoureido) Derivatives
Molecules 2000, 5(1), 37-50; doi:10.3390/50100037
Received: 27 May 1999 / Accepted: 29 November 1999 / Published: 21 January 2000
Cited by 4 | PDF Full-text (86 KB)
Abstract
Acid and base initiated cyclization and retrocyclization reactions of the selenoureas 1-6 and isoselenoureas 7-12 to fused 4H-1,3-selenazine and 1,2,3,4-tetrahydropyrimidine-4-one skeletons are reported. Fused 2-acylamino-4H-1,3-selenazine-4-ones 13-18 were formed by the action of concentrated sulfuric acid on acylselenoureas 1-6 or on 2,2-dimethylpropanoylisoselenoureas 10-12 at
[...] Read more.
Acid and base initiated cyclization and retrocyclization reactions of the selenoureas 1-6 and isoselenoureas 7-12 to fused 4H-1,3-selenazine and 1,2,3,4-tetrahydropyrimidine-4-one skeletons are reported. Fused 2-acylamino-4H-1,3-selenazine-4-ones 13-18 were formed by the action of concentrated sulfuric acid on acylselenoureas 1-6 or on 2,2-dimethylpropanoylisoselenoureas 10-12 at room temperature. On the other hand, benzoylisoselenoureas 7-9 were not obtained in this cyclocondensation under the same conditions. The reaction of potassium ethoxide on selenazines 13-18 in the ethanol solution evoked retrocyclization to the starting acylselenoureas 1-6. Both types of the title compounds, i.e. selenoureas 1-6 and isoselenoureas 7-12, were deprotonated in a methanol solution of potassium hydroxide used in an equimolar amount, giving rise to potassium salts 19-24, which were isolated only for the thiophene series. By heating the separated potassium salts 20, 21, 23 and 24 in the methanol solution provided, deacylation and isoselenoureas 26, 27 were formed. The in situ prepared salts 19, 22 cyclized under the same conditions with deacylation to 4-selanyl-3,4-dihydroquinazoline-4-one 28. The title compounds 1-6, 7-12 and products of their deacylation 26, 27 on boiling in methanolic potassium hydroxide cyclized to the corresponding fused 2-selenoxo-1,2,3,4-tetrahydropyrimidine-4-one potassium salts. These compounds provided pyrimidine-4-ones 28-30 on acidification. Acid initiated retrocyclization 28-30 to the corresponding 2-amino-4H-1,3-selenazine-4-ones was unsuccessful. C, H, N, Se elemental analyses, FTIR, 1H-NMR, and 13C-NMR spectroscopies supported the structure of synthesized compounds.A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives. Full article
Open AccessArticle A High-Yielding Synthesis of the Naturally Occurring Antitumour Agent Irisquinone
Molecules 2000, 5(1), 82-88; doi:10.3390/50100082
Received: 2 November 1999 / Accepted: 12 January 2000 / Published: 18 January 2000
Cited by 5 | PDF Full-text (37 KB)
Abstract A short, high-yielding synthesis of the antitumour agent irisquinone (1) is described. The key steps are the palladium catalysed coupling reaction of dec-9-yn-1-ol with iodide (2) to form alkyne (3) and the Fremy’s salt oxidation of phenol (7). Full article
Open AccessArticle Substituted Pyrroles
Molecules 2000, 5(1), 89-92; doi:10.3390/50100089
Received: 14 December 1999 / Accepted: 22 January 2000 / Published: 26 January 2000
PDF Full-text (15 KB)
Abstract A stepwise synthesis of a-unsubstituted pyrroles with desired substituents in the b-positions of the ring has been devised. Full article
Open AccessArticle JChemPaint - Using the Collaborative Forces of the Internet to Develop a Free Editor for 2D Chemical Structures
Molecules 2000, 5(1), 93-98; doi:10.3390/50100093
Received: 26 January 2000 / Accepted: 27 January 2000 / Published: 28 January 2000
Cited by 25 | PDF Full-text (186 KB)
Abstract The open source program for drawing 2D chemical structures JChemPaint, its current features, its envisioned further development and the principles enabling researchers and students at places all over the world to collaboratively develop such a program are described. Full article

Review

Jump to: Editorial, Research, Other

Open AccessReview Recent Developments in the Area of Asymmetric Transfer Hydrogenation
Molecules 2000, 5(1), 4-18; doi:10.3390/50100004
Received: 14 September 2000 / Accepted: 15 November 2000 / Published: 21 January 2001
Cited by 24 | PDF Full-text (88 KB)
Abstract
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions.
[...] Read more.
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of a-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom. Full article
Open AccessReview A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues
Molecules 2000, 5(1), 51-81; doi:10.3390/50100051
Received: 14 November 1999 / Accepted: 9 December 1999 / Published: 21 January 2000
Cited by 36 | PDF Full-text (181 KB)
Abstract A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives. Full article

Other

Jump to: Editorial, Research, Review

Open AccessShort Note 2-Ethoxycarbonyl-3-(2-furyl)-5-hydroxy-5-methylcyclohexanone
Molecules 2000, 5(1), M127; doi:10.3390/M127
Received: 26 November 1999 / Accepted: 15 December 1999 / Published: 24 January 2000
PDF Full-text (93 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 4-Furyl-6-hydroxy-6-methyl-1,2,4,5,6,7-hexahydro-3H-indazole-3-one
Molecules 2000, 5(1), M128; doi:10.3390/M128
Received: 26 November 1999 / Accepted: 15 December 1999 / Published: 24 January 2000
PDF Full-text (91 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note N-(3-Trifluoromethylphenyl)-4-nitroaniline
Molecules 2000, 5(1), M129; doi:10.3390/M129
Received: 25 November 1999 / Accepted: 15 December 1999 / Published: 24 January 2000
PDF Full-text (87 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 1-(6-Amino-9H-purin-9-yl)-3-diazoacetone
Molecules 2000, 5(1), M130; doi:10.3390/M130
Received: 21 December 1999 / Accepted: 14 January 2000 / Published: 24 January 2000
Cited by 1 | PDF Full-text (91 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Methane-diphosphonic Acid Tetraethyl Ester
Molecules 2000, 5(1), M131; doi:10.3390/M131
Received: 16 December 1999 / Accepted: 17 January 2000 / Published: 24 January 2000
Cited by 2 | PDF Full-text (96 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 4-Hydroxy-6-methyl-3-nitroso-1-phenethyl-2(1H)-pyridinone
Molecules 2000, 5(1), M132; doi:10.3390/M132
Received: 10 January 2000 / Accepted: 14 January 2000 / Published: 24 January 2000
PDF Full-text (88 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Copper 1,14:7,8-Diethenotetrapyrido-[2,1,6-de:2',1',6'-gh:2'',1'',6'''-na][1,3,5,8,10,12]hexaazacyclotetradecine Trifluoroacetate
Molecules 2000, 5(1), M133; doi:10.3390/M133
Received: 29 December 1999 / Accepted: 17 January 2000 / Published: 24 January 2000
PDF Full-text (94 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

Journal Contact

MDPI AG
Molecules Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
molecules@mdpi.com
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
Editorial Board
Contact Details Submit to Molecules
Back to Top