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Int. J. Mol. Sci. 2012, 13(12), 15496-15509; doi:10.3390/ijms131215496
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Identification of kakusei, a Nuclear Non-Coding RNA, as an Immediate Early Gene from the Honeybee, and Its Application for Neuroethological Study

1,* , 2
,
2
 and
2
1 Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan 2 Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
* Author to whom correspondence should be addressed.
Received: 29 October 2012 / Revised: 16 November 2012 / Accepted: 19 November 2012 / Published: 22 November 2012
(This article belongs to the Special Issue Non-Coding RNAs 2012)
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Abstract

The honeybee is a social insect that exhibits various social behaviors. To elucidate the neural basis of honeybee behavior, we detected neural activity in freely-moving honeybee workers using an immediate early gene (IEG) that is expressed in a neural activity-dependent manner. In European honeybees (Apis mellifera), we identified a novel nuclear non-coding RNA, termed kakusei, as the first insect IEG, and revealed the neural activity pattern in foragers. In addition, we isolated a homologue of kakusei, termed Acks, from the Japanese honeybee (Apis cerana), and detected active neurons in workers fighting with the giant hornet.
Keywords: honeybee; kakusei; immediate early gene; insect; brain; non-coding RNA; foraging behavior; dance communication; Japanese honeybee; hot defensive bee ball formation honeybee; kakusei; immediate early gene; insect; brain; non-coding RNA; foraging behavior; dance communication; Japanese honeybee; hot defensive bee ball formation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kiya, T.; Ugajin, A.; Kunieda, T.; Kubo, T. Identification of kakusei, a Nuclear Non-Coding RNA, as an Immediate Early Gene from the Honeybee, and Its Application for Neuroethological Study. Int. J. Mol. Sci. 2012, 13, 15496-15509.

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