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Article

10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer

by
Chung-Yi Chen
1,
Kuo-Chen Cheng
2,3,4,
Andy Y Chang
5,6,
Ying-Ting Lin
7,
You-Cheng Hseu
8 and
Hui-Min Wang
6,*
1
Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, 151, Ching-Hsueh Road, Ta-Liao District, Kaohsiung 83102, Taiwan
2
Department of Internal Medicine, Chi-Mei Medical Centre, Tainan 710, Taiwan
3
Department of Safety Health and Environment, Chung Hwa University of Medical Technology, Tainan 717, Taiwan
4
Department of Medicine, National Defense Medical Center, Taipei 114, Taiwan
5
Department of Biology, University of California, Riverside, Riverside, CA 92521, USA
6
Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, Taiwan
7
Department of Biotechnology, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
8
Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2012, 13(2), 1762-1777; https://doi.org/10.3390/ijms13021762
Submission received: 22 December 2011 / Revised: 9 January 2012 / Accepted: 13 January 2012 / Published: 8 February 2012
(This article belongs to the Special Issue Antioxidants)
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Abstract

In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
Keywords: ginger; 10-shogaol; antioxidant activities; skin cell; proliferation; growth factors; migration ginger; 10-shogaol; antioxidant activities; skin cell; proliferation; growth factors; migration

Share and Cite

MDPI and ACS Style

Chen, C.-Y.; Cheng, K.-C.; Chang, A.Y.; Lin, Y.-T.; Hseu, Y.-C.; Wang, H.-M. 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. Int. J. Mol. Sci. 2012, 13, 1762-1777. https://doi.org/10.3390/ijms13021762

AMA Style

Chen C-Y, Cheng K-C, Chang AY, Lin Y-T, Hseu Y-C, Wang H-M. 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. International Journal of Molecular Sciences. 2012; 13(2):1762-1777. https://doi.org/10.3390/ijms13021762

Chicago/Turabian Style

Chen, Chung-Yi, Kuo-Chen Cheng, Andy Y Chang, Ying-Ting Lin, You-Cheng Hseu, and Hui-Min Wang. 2012. "10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer" International Journal of Molecular Sciences 13, no. 2: 1762-1777. https://doi.org/10.3390/ijms13021762

APA Style

Chen, C.-Y., Cheng, K.-C., Chang, A. Y., Lin, Y.-T., Hseu, Y.-C., & Wang, H.-M. (2012). 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. International Journal of Molecular Sciences, 13(2), 1762-1777. https://doi.org/10.3390/ijms13021762

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