Consequences of Morphology on Molecularly Imprinted Polymer-Ligand Recognition
AbstractThe relationship between molecularly imprinted polymer (MIP) morphology and template-rebinding over a series of warfarin-imprinted methacrylic acid co(ethylene dimethacrylate) polymers has been explored. Detailed investigations of the nature of template recognition revealed that an optimal template binding was obtained with polymers possessing a narrow population of pores (~3–4 nm) in the mesopore size range. Importantly, the warfarin-polymer rebinding analyses suggest strategies for regulating ligand binding capacity and specificity through variation of the degree of cross-linking, where polymers prepared with a lower degree of cross-linking afford higher capacity though non-specific in character. In contrast, the co-existence of specific and non-specific binding was found in conjunction with higher degrees of cross-linking and resultant meso- and macropore size distributions.
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Rosengren, A.M.; Karlsson, B.C.G.; Nicholls, I.A. Consequences of Morphology on Molecularly Imprinted Polymer-Ligand Recognition. Int. J. Mol. Sci. 2013, 14, 1207-1217.
Rosengren AM, Karlsson BCG, Nicholls IA. Consequences of Morphology on Molecularly Imprinted Polymer-Ligand Recognition. International Journal of Molecular Sciences. 2013; 14(1):1207-1217.Chicago/Turabian Style
Rosengren, Annika M.; Karlsson, Björn C.G.; Nicholls, Ian A. 2013. "Consequences of Morphology on Molecularly Imprinted Polymer-Ligand Recognition." Int. J. Mol. Sci. 14, no. 1: 1207-1217.