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Int. J. Mol. Sci. 2013, 14(5), 9628-9642; doi:10.3390/ijms14059628

Molecular Motors and Apical CFTR Traffic in Epithelia

1 Department of Pediatrics/Gastroenterology & Hepatology, School of Medicine, Yale University, New Haven, CT 06520, USA 2 Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT 06520, USA
* Author to whom correspondence should be addressed.
Received: 7 April 2013 / Revised: 19 April 2013 / Accepted: 2 May 2013 / Published: 3 May 2013
(This article belongs to the Special Issue Regulation of Membrane Trafficking and Its Potential Implications)
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Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement of protein motors in CFTR traffic is cell-type specific. Understanding motor specificity provides insight into the biology of the channel and opens opportunity for discovery of organ-specific drug targets for treating CFTR-mediated diseases.
Keywords: CFTR; trafficking; myosins; microtubules; actin transport CFTR; trafficking; myosins; microtubules; actin transport
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kravtsov, D.V.; Ameen, N.A. Molecular Motors and Apical CFTR Traffic in Epithelia. Int. J. Mol. Sci. 2013, 14, 9628-9642.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert