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Int. J. Mol. Sci. 2013, 14(5), 9628-9642; doi:10.3390/ijms14059628
Review

Molecular Motors and Apical CFTR Traffic in Epithelia

1
 and
1,2,*
1 Department of Pediatrics/Gastroenterology & Hepatology, School of Medicine, Yale University, New Haven, CT 06520, USA 2 Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT 06520, USA
* Author to whom correspondence should be addressed.
Received: 7 April 2013 / Revised: 19 April 2013 / Accepted: 2 May 2013 / Published: 3 May 2013
(This article belongs to the Special Issue Regulation of Membrane Trafficking and Its Potential Implications)
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Abstract

Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement of protein motors in CFTR traffic is cell-type specific. Understanding motor specificity provides insight into the biology of the channel and opens opportunity for discovery of organ-specific drug targets for treating CFTR-mediated diseases.
Keywords: CFTR; trafficking; myosins; microtubules; actin transport CFTR; trafficking; myosins; microtubules; actin transport
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kravtsov, D.V.; Ameen, N.A. Molecular Motors and Apical CFTR Traffic in Epithelia. Int. J. Mol. Sci. 2013, 14, 9628-9642.

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