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Int. J. Mol. Sci. 2013, 14(9), 18488-18501; doi:10.3390/ijms140918488

Novel Strategies for the Prevention and Treatment of Biofilm Related Infections

1 Nanova, Inc. Columbia, MO 65211, USA 2 Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA 3 Division of Cardiovascular Medicine, Department of Internal Medicine, University of Missouri, Columbia, MO 65212, USA
* Author to whom correspondence should be addressed.
Received: 8 August 2013 / Revised: 28 August 2013 / Accepted: 30 August 2013 / Published: 6 September 2013
(This article belongs to the Special Issue Biofilms: Extracellular Bastions of Bacteria)
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Biofilm formation by human bacterial pathogens on implanted medical devices causes major morbidity and mortality among patients, and leads to billions of dollars in healthcare cost. Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. As a result, novel therapeutic solutions other than the conventional antibiotic therapies are in urgent need. In this review, we will discuss the recent research in discovery of alternative approaches to prevent or treat biofilms. Current anti-biofilm technologies could be divided into two groups. The first group focuses on targeting the biofilm forming process of bacteria based on our understanding of the molecular mechanism of biofilm formation. Small molecules and enzymes have been developed to inhibit or disrupt biofilm formation. Another group of anti-biofilm technologies focuses on modifying the biomaterials used in medical devices to make them resistant to biofilm formation. While these novel anti-biofilm approaches are still in nascent phases of development, efforts devoted to these technologies could eventually lead to anti-biofilm therapies that are superior to the current antibiotic treatment.
Keywords: biofilm; antimicrobial; small molecule; biomaterial biofilm; antimicrobial; small molecule; biomaterial
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, M.; Yu, Q.; Sun, H. Novel Strategies for the Prevention and Treatment of Biofilm Related Infections. Int. J. Mol. Sci. 2013, 14, 18488-18501.

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