Next Article in Journal
Long Non-Coding RNAs and Complex Human Diseases
Next Article in Special Issue
Engineering Lipid Bilayer Membranes for Protein Studies
Previous Article in Journal
The MAPKKK Gene Family in Gossypium raimondii: Genome-Wide Identification, Classification and Expression Analysis
Previous Article in Special Issue
Interaction between Dipolar Lipid Headgroups and Charged Nanoparticles Mediated by Water Dipoles and Ions
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2013, 14(9), 18758-18789; doi:10.3390/ijms140918758

Peptide-Lipid Interactions: Experiments and Applications

1
Department of Pharmacy, CIRPEB and DFM—University of Naples "Federico II", Via Mezzocannone 16, 80134 Napoli, Italy
2
Institute of Biostructures and Bioimages—CNR, Via Mezzocannone 16, 80134 Napoli, Italy
3
Department of Experimental Medicine—Second University of Naples, Via De Crecchio 7, 80138 Napoli, Italy
*
Authors to whom correspondence should be addressed.
Received: 18 June 2013 / Revised: 27 August 2013 / Accepted: 28 August 2013 / Published: 12 September 2013
(This article belongs to the Special Issue Computational Modelling of Biological Membranes)
View Full-Text   |   Download PDF [1095 KB, uploaded 19 June 2014]   |  

Abstract

The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated cellular processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. Moreover, a major goal of modern biotechnology is obtaining new potent pharmaceutical agents whose biological action is dependent on the binding of peptides to lipid-bilayers. Several issues need to be addressed such as secondary structure, orientation, oligomerization and localization inside the membrane. At the same time, the structural effects which the peptides cause on the lipid bilayer are important for the interactions and need to be elucidated. The structural characterization of membrane active peptides in membranes is a harsh experimental challenge. It is in fact accepted that no single experimental technique can give a complete structural picture of the interaction, but rather a combination of different techniques is necessary. View Full-Text
Keywords: peptide; membrane; bacteria; virus peptide; membrane; bacteria; virus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Galdiero, S.; Falanga, A.; Cantisani, M.; Vitiello, M.; Morelli, G.; Galdiero, M. Peptide-Lipid Interactions: Experiments and Applications. Int. J. Mol. Sci. 2013, 14, 18758-18789.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top