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Int. J. Mol. Sci. 2013, 14(9), 18790-18808; doi:10.3390/ijms140918790

Long Non-Coding RNAs and Complex Human Diseases

Bioinformatics Research Group, Key Laboratory of Intelligent Information Processing, Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China
Department of Molecular and Cell Biology, Center for Systems Biology, University of Texas at Dallas, 800 W Campbell Road, Richardson, TX 75080, USA
Present address: School of Medicine, Tsinghua University, Beijing 100084, China.
Authors to whom correspondence should be addressed.
Received: 20 June 2013 / Revised: 28 August 2013 / Accepted: 3 September 2013 / Published: 12 September 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs 2013)
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Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are generally defined as non-protein-coding transcripts longer than 200 nucleotides. Recently, an increasing number of studies have shown that lncRNAs can be involved in various critical biological processes, such as chromatin remodeling, gene transcription, and protein transport and trafficking. Moreover, lncRNAs are dysregulated in a number of complex human diseases, including coronary artery diseases, autoimmune diseases, neurological disorders, and various cancers, which indicates their important roles in these diseases. Here, we reviewed the current understanding of lncRNAs, including their definition and subclassification, regulatory functions, and potential roles in different types of complex human diseases.
Keywords: non-coding RNA; long non-coding RNA; complex human disease non-coding RNA; long non-coding RNA; complex human disease
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, J.; Xuan, Z.; Liu, C. Long Non-Coding RNAs and Complex Human Diseases. Int. J. Mol. Sci. 2013, 14, 18790-18808.

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