Potential Therapeutic Roles of Tanshinone IIA in Human Bladder Cancer Cells
AbstractTanshinone IIA (Tan-IIA), one of the major lipophilic components isolated from the root of Salviae Miltiorrhizae, has been found to exhibit anticancer activity in various cancer cells. We have demonstrated that Tan-IIA induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. Here we explored the anticancer effect of Tan-IIA in human bladder cancer cell lines. Our results showed that Tan-IIA caused bladder cancer cell death in a time- and dose-dependent manner. Tan-IIA induced apoptosis through the mitochondria-dependent pathway in these bladder cancer cells. Tan-IIA also suppressed the migration of bladder cancer cells as revealed by the wound healing and transwell assays. Finally, combination therapy of Tan-IIA with a lower dose of cisplatin successfully killed bladder cancer cells, suggesting that Tan-IIA can serve as a potential anti-cancer agent in bladder cancer. View Full-Text
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Chiu, S.-C.; Huang, S.-Y.; Chang, S.-F.; Chen, S.-P.; Chen, C.-C.; Lin, T.-H.; Liu, H.-H.; Tsai, T.-H.; Lee, S.-S.; Pang, C.-Y.; Hsieh, T.-F. Potential Therapeutic Roles of Tanshinone IIA in Human Bladder Cancer Cells. Int. J. Mol. Sci. 2014, 15, 15622-15637.
Chiu S-C, Huang S-Y, Chang S-F, Chen S-P, Chen C-C, Lin T-H, Liu H-H, Tsai T-H, Lee S-S, Pang C-Y, Hsieh T-F. Potential Therapeutic Roles of Tanshinone IIA in Human Bladder Cancer Cells. International Journal of Molecular Sciences. 2014; 15(9):15622-15637.Chicago/Turabian Style
Chiu, Sheng-Chun; Huang, Sung-Ying; Chang, Shu-Fang; Chen, Shee-Ping; Chen, Chi-Cheng; Lin, Tien-Huang; Liu, Hsin-Ho; Tsai, Tsung-Hsun; Lee, Shang-Sen; Pang, Cheng-Yoong; Hsieh, Teng-Fu. 2014. "Potential Therapeutic Roles of Tanshinone IIA in Human Bladder Cancer Cells." Int. J. Mol. Sci. 15, no. 9: 15622-15637.