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Int. J. Mol. Sci. 2017, 18(4), 886; doi:10.3390/ijms18040886

Circadian Rhythm Neuropeptides in Drosophila: Signals for Normal Circadian Function and Circadian Neurodegenerative Disease

1
Department of Entomology, China Agricultural University, 2# Yuanmingyuan West Road, Beijing 100193, China
2
Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri–Kansas City, 5100 Rockhill Rd., Kansas City, MO 64110, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Irina V. Zhdanova
Received: 30 March 2017 / Revised: 13 April 2017 / Accepted: 18 April 2017 / Published: 21 April 2017
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Circadian Rhythms)
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Abstract

Circadian rhythm is a ubiquitous phenomenon in many organisms ranging from prokaryotes to eukaryotes. During more than four decades, the intrinsic and exogenous regulations of circadian rhythm have been studied. This review summarizes the core endogenous oscillation in Drosophila and then focuses on the neuropeptides, neurotransmitters and hormones that mediate its outputs and integration in Drosophila and the links between several of these (pigment dispersing factor (PDF) and insulin-like peptides) and neurodegenerative disease. These signaling molecules convey important network connectivity and signaling information for normal circadian function, but PDF and insulin-like peptides can also convey signals that lead to apoptosis, enhanced neurodegeneration and cognitive decline in flies carrying circadian mutations or in a senescent state. View Full-Text
Keywords: circadian rhythm mechanism; circadian neuropeptides; PDF; NPF; ILP; Alzheimer’s disease; tauopathy; apoptosis circadian rhythm mechanism; circadian neuropeptides; PDF; NPF; ILP; Alzheimer’s disease; tauopathy; apoptosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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He, Q.; Wu, B.; Price, J.L.; Zhao, Z. Circadian Rhythm Neuropeptides in Drosophila: Signals for Normal Circadian Function and Circadian Neurodegenerative Disease. Int. J. Mol. Sci. 2017, 18, 886.

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