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Int. J. Mol. Sci. 2018, 19(1), 240; doi:10.3390/ijms19010240

Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer

1
Department of Surgery, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
2
Molecular Oncology Laboratories, Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
*
Author to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 8 January 2018 / Accepted: 9 January 2018 / Published: 13 January 2018
(This article belongs to the Special Issue Molecular Pathways of Estrogen Receptor Action)
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Abstract

Hormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor alpha and androgen receptor in breast cancer and prostate cancer, are critical to cancer cell proliferation and tumor growth. In this review we focused on the cross-talk between hormone and hypoxia pathways, particularly in breast cancer. We delineated a novel signaling pathway from estrogen receptor to hypoxia-inducible factor 1, and discussed the role of this pathway in endocrine therapy resistance. Further, we discussed the estrogen and hypoxia pathways converging at histone demethylase KDM4B, an important epigenetic modifier in cancer. View Full-Text
Keywords: estrogen receptor alpha; hypoxia-inducible factor 1; KDM4B; endocrine therapy resistance estrogen receptor alpha; hypoxia-inducible factor 1; KDM4B; endocrine therapy resistance
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Yang, J.; Harris, A.L.; Davidoff, A.M. Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer. Int. J. Mol. Sci. 2018, 19, 240.

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