Maternal Fructose Intake Affects Transcriptome Changes and Programmed Hypertension in Offspring in Later Life
Abstract
:1. Introduction
2. Metabolic Effects of Fructose on Renal Biology and Hypertension
3. Effect of Maternal Fructose Consumption on Programmed Hypertension
4. HF Consumption Induces Renal Transcriptome Changes
5. Reprogramming Strategy to Prevent Maternal HF Consumption-Induced Programmed Hypertension
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Types of Fructose Intake | Strain | Programming Effects | Age at Which the Effects Were Measured | References |
---|---|---|---|---|
10% w/v fructose plus 4% NaCl in drinking water 28 days before conception and throughout gestation and lactation | Male Sprague–Dawley rats | ↑ systolic BP, ↑ mean arterial BP | At 9 weeks of age | [26] |
60% HF diet throughout pregnancy and lactation | Male Sprague–Dawley rats | ↑ systolic BP, ↑ mean arterial BP | At 12 weeks of age | [27,28,29] |
60% HF diet throughout pregnancy and lactation | Male and female Sprague–Dawley rats | ↑ systolic BP | At 12 weeks of age | [30] |
60% HF diet throughout pregnancy and lactation plus 1% NaCl in drinking water from weaning to 3 months of age | Male Sprague–Dawley rats | ↑ systolic BP, ↑ mean arterial BP; postnatal high-salt aggravates prenatal HF-induced programmed hypertension | At 12 weeks of age | [31] |
56.7% HF/high-fat diet throughout pregnancy and lactation | Male Sprague–Dawley rats | ↑ mean arterial BP | At 16 weeks of age | [32] |
10% w/v fructose in drinking water throughout pregnancy and lactation | C57BL/6J mice | ↑ mean arterial BP, obesity, metabolic dysfunction | At 12 months of age | [33] |
Gene ID | Symbol | Kidney | Brain | Heart |
---|---|---|---|---|
Fructose and mannose metabolism | ||||
ENSRNOG00000001214 | Pfkl | 2.3 | 1.5 | 2.2 |
ENSRNOG00000006116 | Hk2 | 1.8 | ND | 2.1 |
ENSRNOG00000018911 | Pfkfb3 | 1.8 | ND | 4.5 |
Adipocytokine signaling pathway | ||||
ENSRNOG00000002946 | Socs3 | 1.6 | 0.5 | 3.9 |
ENSRNOG00000007390 | Nfkbia | 1.9 | 1.9 | 3.5 |
ENSRNOG00000004473 | Ppargc1a | 2.3 | 1.6 | 2.7 |
ENSRNOG00000007284 | Slc2a1 | 3.0 | 2.3 | ND |
ENSRNOG00000023509 | Irs2 | 2.1 | ND | 1.6 |
Glycolysis/Gluconeogenesis | ||||
ENSRNOG00000001214 | Pfkl | 2.3 | 1.5 | 2.2 |
ENSRNOG00000006116 | Hk2 | 1.8 | ND | 2.1 |
ENSRNOG00000013009 | Ldha | 2.2 | ND | 1.6 |
Fatty acid metabolism | ||||
ENSRNOG00000020624 | Acadsb | 1.9 | 2.0 | ND |
Insulin signaling pathway | ||||
ENSRNOG00000002946 | Socs3 | 1.6 | 0.5 | 3.9 |
ENSRNOG00000004473 | Ppargc1a | 2.3 | 1.6 | 2.7 |
ENSRNOG00000006388 | Pygl | 1.9 | ND | 3.2 |
ENSRNOG00000006116 | Hk2 | 1.8 | ND | 2.1 |
ENSRNOG00000023509 | Irs2 | 2.1 | ND | 1.6 |
ENSRNOG00000003463 | Srebf1 | 2.1 | ND | 1.6 |
ENSRNOG00000013397 | Foxo1 | 1.8 | ND | 2.2 |
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Tain, Y.-L.; Chan, J.Y.H.; Hsu, C.-N. Maternal Fructose Intake Affects Transcriptome Changes and Programmed Hypertension in Offspring in Later Life. Nutrients 2016, 8, 757. https://doi.org/10.3390/nu8120757
Tain Y-L, Chan JYH, Hsu C-N. Maternal Fructose Intake Affects Transcriptome Changes and Programmed Hypertension in Offspring in Later Life. Nutrients. 2016; 8(12):757. https://doi.org/10.3390/nu8120757
Chicago/Turabian StyleTain, You-Lin, Julie Y. H. Chan, and Chien-Ning Hsu. 2016. "Maternal Fructose Intake Affects Transcriptome Changes and Programmed Hypertension in Offspring in Later Life" Nutrients 8, no. 12: 757. https://doi.org/10.3390/nu8120757