Table of Contents
Toxins, Volume 10, Issue 5 (May 2018)
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Cover Story (view full-size image) The cyclophilin inhibitor cyclosporine A protects cells from intoxication with pertussis toxin by [...] Read more. The cyclophilin inhibitor cyclosporine A protects cells from intoxication with pertussis toxin by reducing the amount of the enzymatic subunit PTS1 of this toxin in the cytosol of target cells demonstrated by fluorescence microscopy. Thereby, the ADP-ribosylation of inhibitory alpha subunits of trimeric G proteins by PTS1 is reduced and the subsequent disturbed signaling causing the severe symptoms of whooping cough averted. Thus, cyclophilin inhibitors might represent promising starting points for development of novel therapeutic strategies against whooping cough. Blue = nucleus, Green = F-actin, Red = PTS1. View the paper here.