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Toxins 2017, 9(9), 278; doi:10.3390/toxins9090278

Total Body Irradiation Mitigates Inflammation and Extends the Therapeutic Time Window for Anti-Ricin Antibody Treatment against Pulmonary Ricinosis in Mice

Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100, Israel
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editors: Daniel Gillet and Julien Barbier
Received: 16 August 2017 / Revised: 5 September 2017 / Accepted: 9 September 2017 / Published: 11 September 2017
(This article belongs to the Special Issue Ribosome Inactivating Toxins)
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Abstract

Ricin, a highly toxic plant-derived toxin, is considered a potential weapon in biowarfare and bioterrorism due to its pronounced toxicity, high availability, and ease of preparation. Pulmonary exposure to ricin results in the generation of an acute edematous inflammation followed by respiratory insufficiency and death. Massive neutrophil recruitment to the lungs may contribute significantly to ricin-mediated morbidity. In this study, total body irradiation (TBI) served as a non-pharmacological tool to decrease the potential neutrophil-induced lung injury. TBI significantly postponed the time to death of intranasally ricin-intoxicated mice, given that leukopenia remained stable following intoxication. This increase in time to death coincided with a significant reduction in pro-inflammatory marker levels, and led to marked extension of the therapeutic time window for anti-ricin antibody treatment. View Full-Text
Keywords: ricin; total body irradiation; leukopenia; neutropenia; inflammation ricin; total body irradiation; leukopenia; neutropenia; inflammation
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MDPI and ACS Style

Gal, Y.; Sapoznikov, A.; Falach, R.; Ehrlich, S.; Aftalion, M.; Kronman, C.; Sabo, T. Total Body Irradiation Mitigates Inflammation and Extends the Therapeutic Time Window for Anti-Ricin Antibody Treatment against Pulmonary Ricinosis in Mice. Toxins 2017, 9, 278.

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