Next Article in Journal
Trophic Actions of Bone Marrow-Derived Mesenchymal Stromal Cells for Muscle Repair/Regeneration
Next Article in Special Issue
Unfolded Protein Responses With or Without Unfolded Proteins?
Previous Article in Journal / Special Issue
p53 -Dependent and -Independent Nucleolar Stress Responses
Cells 2012, 1(4), 799-831; doi:10.3390/cells1040799

Multiple Strategies for Translesion Synthesis in Bacteria

1 Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA 2 Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA 3 Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, MA 02115, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 6 August 2012 / Revised: 29 September 2012 / Accepted: 30 September 2012 / Published: 15 October 2012
(This article belongs to the Special Issue Cellular Stress Response)
View Full-Text   |   Download PDF [362 KB, uploaded 15 October 2012]   |   Browse Figures


Damage to DNA is common and can arise from numerous environmental and endogenous sources. In response to ubiquitous DNA damage, Y-family DNA polymerases are induced by the SOS response and are capable of bypassing DNA lesions. In Escherichia coli, these Y-family polymerases are DinB and UmuC, whose activities are modulated by their interaction with the polymerase manager protein UmuD. Many, but not all, bacteria utilize DinB and UmuC homologs. Recently, a C-family polymerase named ImuC, which is similar in primary structure to the replicative DNA polymerase DnaE, was found to be able to copy damaged DNA and either carry out or suppress mutagenesis. ImuC is often found with proteins ImuA and ImuB, the latter of which is similar to Y‑family polymerases, but seems to lack the catalytic residues necessary for polymerase activity. This imuAimuBimuC mutagenesis cassette represents a widespread alternative strategy for translesion synthesis and mutagenesis in bacteria. Bacterial Y‑family and ImuC DNA polymerases contribute to replication past DNA damage and the acquisition of antibiotic resistance.
Keywords: DNA damage; mutagenesis; SOS response; DNA pol IV (DinB); DNA pol V (UmuD'2C); dnaE; dnaE2; imuA; imuB; imuC DNA damage; mutagenesis; SOS response; DNA pol IV (DinB); DNA pol V (UmuD' 2C); dnaE; dnaE2; imuA; imuB; imuC
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Ippoliti, P.J.; DeLateur, N.A.; Jones, K.M.; Beuning, P.J. Multiple Strategies for Translesion Synthesis in Bacteria. Cells 2012, 1, 799-831.

View more citation formats

Related Articles

Article Metrics


[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert