Special Issue "Cellular Stress Response"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 July 2012)
Dr. Alex Almasan (Website)
Department of Cancer Biology, Bridge appointment with Department of Radiation Oncology, Taussig Cancer Institute, Lerner Research Institute / NB40, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Interests: apoptosis; autophagy; cancer (leukemia and prostate); cell death; cell cycle; DNA damage and repair
Cells are constantly subjected to various forms of endogenous and exogenous stress that shapes their existence. How they respond to it depends on exogenous factors and their ability to handle the stress to which they are exposed. Examples of cellular stress are the DNA damage caused by radiation, chemotherapy, hypoxia, oncogene activation; these will ultimately lead to transient or permanent (senescence) growth arrest, or if the damage is severe, death that ultimately eliminates the damaged cells . Whether cells mount a protective response or succumb to death depends to a large extent on the nature and duration of the stress and the particular cell type. How such cellular stress leads to activation of pro-survival molecules that may activate repair of DNA damage in the nucleus or in the cytoplasm by autophagy (see dedicated special issue) and/or prevent cell death is of considerable interest. Moreover, alternative splicing and the adaptive response are of special interest.
This Special Issue offers an Open Access forum that aims at bringing together a collection of original research and review articles addressing recent developments in the cellular stress response, the signaling pathways that mitigate its biological effects and the ensuing cell proliferation and/or survival outcomes.
Dr. Alex Almasan
- Cell cycle arrest
- Cellular stress
- DNA repair
- Genotoxic stress
- Oncogene activation
- Oxidative stress
- Programmed cell death