Rectal Cancer in a Patient with Bartter Syndrome: A Case Report
AbstractA woman with rectal cancer was scheduled for surgery. However, she also had hypokalemia, hyperreninemia, and hyperaldosteronism in the absence of any known predisposing factors or endocrine tumors. She was given intravenous potassium, and her blood abnormalities stabilized after tumor resection. Genetic analysis revealed mutations in several genes associated with Bartter syndrome (BS) and Gitelman syndrome, including SLC12A1, CLCNKB, CASR, SLC26A3, and SLC12A3. Prostaglandin E2 (PGE2) plays an important role in BS and worsens electrolyte abnormalities. The PGE2 level is reportedly increased in colorectal cancer, and in the present case, immunohistochemical examination revealed an increased PGE2 level in the tumor. We concluded that the tumor-related PGE2 elevation had worsened the patient’s BS, which became more manageable after tumor resection. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 958 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Fujino, S.; Miyoshi, N.; Ohue, M.; Mukai, M.; Kukita, Y.; Hata, T.; Matsuda, C.; Mizushima, T.; Doki, Y.; Mori, M. Rectal Cancer in a Patient with Bartter Syndrome: A Case Report. Genes 2017, 8, 139.
Fujino S, Miyoshi N, Ohue M, Mukai M, Kukita Y, Hata T, Matsuda C, Mizushima T, Doki Y, Mori M. Rectal Cancer in a Patient with Bartter Syndrome: A Case Report. Genes. 2017; 8(5):139.Chicago/Turabian Style
Fujino, Shiki; Miyoshi, Norikatsu; Ohue, Masayuki; Mukai, Mikio; Kukita, Yoji; Hata, Taishi; Matsuda, Chu; Mizushima, Tsunekazu; Doki, Yuichiro; Mori, Masaki. 2017. "Rectal Cancer in a Patient with Bartter Syndrome: A Case Report." Genes 8, no. 5: 139.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.