Table of Contents
J. Clin. Med., Volume 6, Issue 5 (May 2017)
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Cover Story (view full-size image) Glutathione (L-ϒ-glutamyl-L-cysteinylglycine) is the most abundant intracellular thiol, and the [...] Read more. Glutathione (L-ϒ-glutamyl-L-cysteinylglycine) is the most abundant intracellular thiol, and the intracellular redox state, as reflected by levels of oxidized (GSSG) and reduced (GSH) glutathione, as well as the GSH/GSSG ratio, is considered to be an important indication of cellular health. Individuals affected by mitochondrial disease may have altered glutathione levels, reflecting redox imbalance. Therefore, measuring blood glutathione levels may help ascertain the therapeutic efficacy of drugs that affect mitochondrial function. Several clinical trials over the past few years have focused on developing therapies that have the potential to improve intracellular glutathione status. Measuring glutathione appears to be a promising technique for evaluating mitochondrial function, but the ultimate utility of this biomarker remains under investigation. View the paper here.