Table of Contents
J. Clin. Med., Volume 6, Issue 9 (September 2017)
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Cover Story In acute myeloid leukemia, it has been widely established that persistent residual leukemic burden, [...] Read more. In acute myeloid leukemia, it has been widely established that persistent residual leukemic burden, often referred to as measurable or minimal residual disease (MRD), after induction therapy or at the time of hematopoietic stem cell transplant is highly predictive for adverse clinical outcomes and can be used to identify patients likely to experience clinically evident relapse. In this review, we outline emerging modalities positioned to enhance MRD detection (including modern technologies enabling the digital quantification and tracking of individual DNA or RNA molecules, next-generation sequencing platforms, and high-resolution imaging capabilities) and discuss factors surrounding their integration into clinical practice. View Paper here