Antimicrobial Treatment and Management of Central Nervous System Infections
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: 15 May 2025 | Viewed by 5979
Special Issue Editors
Interests: antibiotic resistance; antimicrobial stewardship; ICU infections; endocarditis; CNS infections
Special Issue Information
Dear Colleagues,
The central nervous system (CNS) might be considered a sanctuary for infections. Transport of fluid and solutes is tightly controlled within the CNS, as the entry of drugs into the cerebrospinal fluid (CSF) is governed by molecular size, lipophilicity, plasma protein binding and their affinity to transport systems at the blood–brain barrier (BBB). For these reasons, CNS infections, especially in hospital settings, are a therapeutic challenge for Specialists of Infectious Diseases (IDs).
In the literature, only a few papers are available regarding therapeutic regimens for hospital-acquired (HA) CNS infections, especially in terms of requiring antibiotics combinations or therapy duration. In the absence of updated guidelines, there is little experience in the use of novel antibiotics in difficult-to-treat pathogens which are increasingly responsible for nosocomial infections in Neurosurgery Departments.
This Special Issue seeks manuscript submissions that deepen our understanding of the treatment and management of CNS infections and broaden our knowledge in this challenging field, in particular regarding HA Infections. Submissions regarding pharmacokinetic studies of novel antibiotics in HA CNS infections are especially encouraged.
Acknowledgment: Silvia Lorenzotti and Barbara Saccani will be participating in this Special Issue as "Special collaborators". We thank them for their contributions.
Dr. Liana Signorini
Dr. Angelo Pan
Guest Editors
Manuscript Submission Information
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Keywords
- central nervous system
- CNS
- hospital-acquired infection
- nosocomial
- neurosurgery
- external ventricular drainage
- EVD
- post-neurosurgical meningitis
- bacterial colonization
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