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Antibiotics
Special Issues
New Insights into the Antimicrobial Bioactivity of Plant-Derived Chemicals
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New Insights into the Antimicrobial Bioactivity of Plant-Derived Chemicals

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2843

Special Issue Editor

Dr. Andrei Mocan

E-Mail Website
Guest Editor
Department of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: plant-derived secondary metabolites; antimicrobials; antioxidants; enzyme inhibition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

From the empirical observations regarding the antimicrobial potential of plant-based phytopreparations to modern trends which are describing the molecular mechanisms of action involved in the antimicrobial activity of plant-derived secondary metabolites, research in this field has continuously focused on offering new perspectives in the fight with infectious diseases. Moreover, recent findings highlight the ability of various phytocompounds to interfere with additional mechanisms involved in microbial resistance, inhibit biofilm formation, or regulate the genetic expression of virulence factors.

Hence, considering the wide range of plant-derived phytochemicals which could influence microbial growth and infective potential of various microbial strains, this Special Issue is focused on the discovery and/or development of plant products with antimicrobial activities, as well as on presenting novel insights regarding advances in antimicrobial activity assessment methods applied to plant-derived phytochemicals.

Dr. Andrei Mocan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural antimicrobials
  • biofilm inhibition
  • antimicrobial resistance
  • resistance factors
  • applications for antibacterial phytochemicals

Published Papers (2 papers)

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Research

24 pages, 581 KiB  
Article
Chemical Analysis and Investigation of Antimicrobial and Antibiofilm Activities of Prangos trifida (Apiaceae)
by Ljuboš Ušjak, Dejan Stojković, Tamara Carević, Violeta Milutinović, Marina Soković, Marjan Niketić and Silvana Petrović
Antibiotics 2024, 13(1), 41; https://doi.org/10.3390/antibiotics13010041 - 01 Jan 2024
Viewed by 1305
Abstract
Plants of the genus Prangos are intensively investigated as potential new sources of bioactive isolated products. In this work, the chemical composition of volatile constituents (essential oils and headspace volatiles) and dichloromethane extracts, as well as antimicrobial and antibiofilm activities of essential oils [...] Read more.
Plants of the genus Prangos are intensively investigated as potential new sources of bioactive isolated products. In this work, the chemical composition of volatile constituents (essential oils and headspace volatiles) and dichloromethane extracts, as well as antimicrobial and antibiofilm activities of essential oils and MFDEs (methanol fractions of dichloromethane extracts) of Prangos trifida from Serbia, were investigated. Volatiles of roots, leaves, stems and fruits, and fatty acids and phytosterols in dichloromethane extracts of roots and fruits were analyzed by GC-FID-MS, whereas coumarins in MFDEs by LC–MS and some isolated coumarins by 1H-NMR. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations/minimum fungicidal concentrations (MBCs/MFCs) of essential oils and MFDEs were determined against 13 microorganisms. Antibiofilm activity was assessed against four microorganisms. Additionally, congo red and ergosterol binding assays were conducted to elucidate selected mechanisms of antibiofilm action in the case of Candida albicans. Total of 52 volatile constituents, 16 fatty acids, eight phytosterols and 10 coumarins were identified. Essential oils demonstrated significant activity, surpassing that of commercial food preservatives, against six tested molds from the Aspergillus, Penicillium and Trichoderma genera, as well as against bacteria Staphylococcus aureus and Bacillus cereus. Most of the oils strongly inhibited the formation of biofilms by S. aureus, Listeria monocytogenes and Escherichia coli. MFDEs exhibited noteworthy effects against B. cereus and the tested Aspergillus species, particularly A. niger, and significantly inhibited C. albicans biofilm formation. This inhibition was linked to a marked reduction in exopolysaccharide production, while antifungal mechanisms associated with ergosterol remained unaffected. Full article
(This article belongs to the Special Issue New Insights into the Antimicrobial Bioactivity of Plant-Derived Chemicals)
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19 pages, 9737 KiB  
Article
Transcriptional Profiling of the Effect of Coleus amboinicus L. Essential Oil against Salmonella Typhimurium Biofilm Formation
by Arpron Leesombun, Sivapong Sungpradit, Ladawan Sariya, Jarupha Taowan and Sookruetai Boonmasawai
Antibiotics 2023, 12(11), 1598; https://doi.org/10.3390/antibiotics12111598 - 07 Nov 2023
Viewed by 1244
Abstract
Salmonella enterica serovar Typhimurium cause infections primarily through foodborne transmission and remains a significant public health concern. The biofilm formation of this bacteria also contributes to their multidrug-resistant nature. Essential oils from medicinal plants are considered potential alternatives to conventional antibiotics. Therefore, this [...] Read more.
Salmonella enterica serovar Typhimurium cause infections primarily through foodborne transmission and remains a significant public health concern. The biofilm formation of this bacteria also contributes to their multidrug-resistant nature. Essential oils from medicinal plants are considered potential alternatives to conventional antibiotics. Therefore, this study assessed the antimicrobial and antibiofilm activities of Coleus amboinicus essential oil (EO-CA) against S. Typhimurium ATCC 14028. Seventeen chemical compounds of EO-CA were identified, and carvacrol (38.26%) was found to be the main constituent. The minimum inhibitory concentration (MIC) of EO-CA for S. Typhimurium planktonic growth was 1024 µg/mL while the minimum bactericidal concentration was 1024 µg/mL. EO-CA at sub-MIC (≥1/16× MIC) exhibited antibiofilm activity against the prebiofilm formation of S. Typhimurium at 24 h. Furthermore, EO-CA (≥1/4× MIC) inhibited postbiofilm formation at 24 and 48 h (p < 0.05). Transcriptional profiling revealed that the EO-CA-treated group at 1/2× MIC had 375 differentially expressed genes (DEGs), 106 of which were upregulated and 269 were downregulated. Five significantly downregulated virulent DEGs responsible for motility (flhD, fljB, and fimD), curli fimbriae (csgD), and invasion (hilA) were screened via quantitative reverse transcription PCR (qRT-PCR). This study suggests the potential of EO-CA as an effective antimicrobial agent for combating planktonic and biofilm formation of Salmonella. Full article
(This article belongs to the Special Issue New Insights into the Antimicrobial Bioactivity of Plant-Derived Chemicals)
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