Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.5
4.8
Journals
Antibiotics
Special Issues
Honey: Antimicrobial and Anti-infective Function
share announcement

Honey: Antimicrobial and Anti-infective Function

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1286

Special Issue Editors

Dr. Niels Cremers

E-Mail Website
Guest Editor
Maastricht University Medical Center, Maastricht, The Netherlands
Interests: medical-grade honey; wound healing; microbiology; biofilms; antimicrobial resistance; candidiasis; complementary and alternative medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Juraj Majtan

E-Mail Website1 Website2
Guest Editor
Laboratory of Apidology and Apitherapy, Department of Microbial Genetics, Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska cesta 21, 845 51 Bratislava, Slovakia
Interests: honeybee products; wound healing; antibacterial activity; immunomodulation
Special Issues, Collections and Topics in MDPI journals
Dr. Katherine Hammer

E-Mail Website1 Website2
Guest Editor
Deputy Director, Graduate Programs in Infectious Diseases School of Biomedical Sciences M504, Perth, WA 6009, Australia
Interests: natural antimicrobial agents; microbial membranes; biofilm; terpenes; sub-inhibitory antimicrobial effects; tolerance and adaptation

Special Issue Information

Dear Colleagues,

Infections are among the leading causes of mortality and morbidity worldwide and can be mediated by bacteria, fungi, or viruses. The increasing antimicrobial resistance is a major challenge and demands novel effective treatment options. For this reason, an increasing amount of attention is being paid to activities related to the use of new or rediscovered preventive and curative approaches within the framework of antimicrobial stewardship. Honey may be a potent solution that has been used in traditional medicine.

Honey exerts a broad-spectrum antimicrobial activity against bacteria, fungi, and viruses, including in cases of antimicrobial resistance. In addition, honey can be used as a pre- and probiotic, can change the microbiota, and has immunomodulatory activities. This combination helps to clear pathogens and makes honey an effective treatment for all kinds of ailments. For example, clinical studies have demonstrated that medical-grade honey (MGH) is effective in the treatment of respiratory diseases, gastrointestinal infections, tuberculosis, mucositis, cold sores, and COVID-19. More studies investigating the antimicrobial activity of honey, its molecular mechanisms, and clinical efficacy in different indications are needed to further implement honey in evidence-based medicine.

This Special Issue welcomes submissions of original research and review articles that investigate the antimicrobial activity and mechanisms of MGH, and the wide range of its clinical applications, including preclinical studies in vitro and/or in vivo, case series, and other clinical studies. 

Dr. Niels Cremers
Dr. Juraj Majtan
Dr. Katherine Hammer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial activity
  • biofilms
  • infections
  • clinical applications

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

15 pages, 1359 KiB  
Review
Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis
by Céline M. J. G. Lardenoije, Senna J. J. M. van Riel, Linsey J. F. Peters, Martine M. L. H. Wassen and Niels A. J. Cremers
Antibiotics 2024, 13(4), 368; https://doi.org/10.3390/antibiotics13040368 - 17 Apr 2024
Viewed by 811
Abstract
The prevalence of bacterial vaginosis (BV) among women of reproductive age is 29%. BV arises from a vaginal imbalance marked by reduced levels of lactic acid-producing lactobacilli and an overgrowth of pathogenic anaerobes. The multifactorial nature of BV’s pathogenesis complicates its treatment. Current [...] Read more.
The prevalence of bacterial vaginosis (BV) among women of reproductive age is 29%. BV arises from a vaginal imbalance marked by reduced levels of lactic acid-producing lactobacilli and an overgrowth of pathogenic anaerobes. The multifactorial nature of BV’s pathogenesis complicates its treatment. Current antibiotic therapy exhibits a recurrence rate of about 60% within a year. Recurrence can be caused by antibiotic treatment failure (e.g., due to antimicrobial resistance), the persistence of residual infections (e.g., due to biofilm formation), and re-infection. Because of the high recurrence rates, alternative therapies are required. Medical-grade honey (MGH), known for its antimicrobial and wound healing properties in wound care, emerges as a potential novel therapy for BV. MGH exerts broad-spectrum antimicrobial activity, employing multiple mechanisms to eliminate the risk of resistance. For example, the low pH of MGH and the production of hydrogen peroxide benefit the microbiota and helps restore the natural vaginal balance. This is supported by in vitro studies demonstrating that MGH has an antibacterial effect on several pathogenic bacteria involved in the pathophysiology of BV, while lactobacilli and the vaginal microenvironment can be positively affected. In contrast to antibiotics, MGH exerts anti-biofilm activity, affects the microbiome as pre- and probiotic, and modulates the vaginal microenvironment through its anti-inflammatory, anti-oxidative, physicochemical, and immunomodulatory properties. More clinical research is required to confirm the positive effect of MGH on BV and to investigate the long-term cure rate. Full article
(This article belongs to the Special Issue Honey: Antimicrobial and Anti-infective Function)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop