Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.5
4.8
Journals
Antibiotics
Special Issues
Organic Synthesis of Drug-Like Antimicrobial Compounds
share announcement

Organic Synthesis of Drug-Like Antimicrobial Compounds

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 2730

Special Issue Editors

Prof. Dr. Diana Camelia Nuta

E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania
Interests: medicinal chemistry; organic synthesis; drug discovery
Prof. Dr. Carmen Limban

E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania
Interests: medicinal chemistry; organic synthesis; drug discovery

Special Issue Information

Dear Colleagues,

Antimicrobials represent a crucial innovation in the field of medicine and possess the potential to significantly reducing the mortality and morbidity associated with infectious diseases. They have also played a pivotal role in advancing modern medicine, enabling procedures like transplantation, cancer chemotherapy, and surgery. Regrettably, the excessive and inappropriate use of antimicrobials in human medicine, as well as in agriculture and veterinary practices, has led to the emergence, proliferation, and spread of antimicrobial resistance (AMR). This is reflected in the alarming prevalence of antibiotic-resistant infections, accompanied by a rise in related mortality rates. In 2019, more than 33,000 patients in Europe lost their lives due to AMR; globally, this figure approached 1.2 million deaths.

The topic of AMR is further compounded by microbial biofilms, which exhibit significantly higher tolerance to antimicrobial agents compared to their planktonic counterparts, sometimes even reaching levels hundreds or thousands of times greater.

The emergence of bacterial infections and the spread of antimicrobial resistance have raised serious global concerns, necessitating urgent action to develop innovative and effective antibacterial strategies. One such approach involves continued efforts to incentivize the design and synthesis of new molecules as potential antimicrobial candidates.

Sharing the findings in this research field will undoubtedly contribute to better preparing the scientific community for the potential challenges of the so-called "post-antibiotic era."

Prof. Dr. Diana Camelia Nuta
Prof. Dr. Carmen Limban
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthesis
  • antimicrobial activity
  • antibacterial
  • antibiofilm
  • microbial resistance

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

16 pages, 6362 KiB  
Article
Antimicrobial Activity of Novel Ni(II) and Zn(II) Complexes with (E)-2-((5-Bromothiazol-2-yl)imino)methyl)phenol Ligand: Synthesis, Characterization and Molecular Docking Studies
by Inas Al-Qadsy, Waseem Sharaf Saeed, Ahmad Abdulaziz Al-Owais, Abdelhabib Semlali, Ali Alrabie, Lena Ahmed Saleh Al-Faqeeh, Mohammed ALSaeedy, Arwa Al-Adhreai, Abdel-Basit Al-Odayni and Mazahar Farooqui
Antibiotics 2023, 12(11), 1634; https://doi.org/10.3390/antibiotics12111634 - 17 Nov 2023
Cited by 1 | Viewed by 1215
Abstract
In order to address the challenges associated with antibiotic resistance by bacteria, two new complexes, Ni(II) and Zn(II), have been synthesized using the conventional method based on Schiff base ligand (E)-2-((5-bromothiazol-2-yl) imino) methyl) phenol. The Schiff base ligand (HL) was synthesized using salicylaldehyde [...] Read more.
In order to address the challenges associated with antibiotic resistance by bacteria, two new complexes, Ni(II) and Zn(II), have been synthesized using the conventional method based on Schiff base ligand (E)-2-((5-bromothiazol-2-yl) imino) methyl) phenol. The Schiff base ligand (HL) was synthesized using salicylaldehyde and 5-(4-bromophenyl)thiazol-2-amine in both traditional and efficient, ecologically friendly, microwave-assisted procedures. The ligand and its complexes were evaluated by elemental analyses, FTIR spectroscopy, UV-Vis spectroscopy, nuclear magnetic resonance (NMR), thermogravimetric analysis (TGA) and magnetic susceptibility. The ligand and its complexes were tested for antibacterial activity against three Gram-positive bacteria (Staphylococcus aureus ATCC 25923, Methicillin-resistant Staphylococcus aureus ATCC 43300 and Enterococcus faecalis ATCC 29212) and three Gram-negative bacteria (Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922 and Klebsiella pneumoniae ATCC 700603). The findings demonstrate the potent activity of the ligand and its complexes against selective bacteria but the Ni(II) complex with MIC values ranging from 1.95 to 7.81 µg/mL outperformed all other compounds, including the widely used antibiotic Streptomycin. Furthermore, the docking study provided evidence supporting the validity of the antimicrobial results, since the Ni complex showed superior binding affinity against to E. coli NAD synthetase, which had a docking score (−7.61 kcal/mol). Full article
(This article belongs to the Special Issue Organic Synthesis of Drug-Like Antimicrobial Compounds)
►▼ Show Figures

Figure 1

Review

Jump to: Research

32 pages, 15808 KiB  
Review
Small Schiff Base Molecules—A Possible Strategy to Combat Biofilm-Related Infections
by Maria Coandă, Carmen Limban and Diana Camelia Nuță
Antibiotics 2024, 13(1), 75; https://doi.org/10.3390/antibiotics13010075 - 12 Jan 2024
Cited by 1 | Viewed by 1233
Abstract
Microorganisms participating in the development of biofilms exhibit heightened resistance to antibiotic treatment, therefore infections involving biofilms have become a problem in recent years as they are more difficult to treat. Consequently, research efforts are directed towards identifying novel molecules that not only [...] Read more.
Microorganisms participating in the development of biofilms exhibit heightened resistance to antibiotic treatment, therefore infections involving biofilms have become a problem in recent years as they are more difficult to treat. Consequently, research efforts are directed towards identifying novel molecules that not only possess antimicrobial properties but also demonstrate efficacy against biofilms. While numerous investigations have focused on antimicrobial capabilities of Schiff bases, their potential as antibiofilm agents remains largely unexplored. Thus, the objective of this article is to present a comprehensive overview of the existing scientific literature pertaining to small molecules categorized as Schiff bases with antibiofilm properties. The survey involved querying four databases (Web of Science, ScienceDirect, Scopus and Reaxys). Relevant articles published in the last 10 years were selected and categorized based on the molecular structure into two groups: classical Schiff bases and oximes and hydrazones. Despite the majority of studies indicating a moderate antibiofilm potential of Schiff bases, certain compounds exhibited a noteworthy effect, underscoring the significance of considering this type of molecular modeling when seeking to develop new molecules with antibiofilm effects. Full article
(This article belongs to the Special Issue Organic Synthesis of Drug-Like Antimicrobial Compounds)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop