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Antibiotics
Special Issues
Development and Biomedical Application of Antibacterial Coatings
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Development and Biomedical Application of Antibacterial Coatings

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: 10 May 2024 | Viewed by 11601

Special Issue Editor

Dr. Selvaraj Rajesh Kumar

E-Mail Website
Guest Editor
Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan City, Taiwan
Interests: antibacterial activities; anticancer activities; targeted drug delivery; implantable coatings; osteoblast compatibility; membranes; polymers; graphene; nanomaterials; composites; fuel cells; electro-catalyst; li-ion/li-air battery; energy storage; nanofiltration; etc.

Special Issue Information

Dear Colleagues,

Human health burdens caused by various microbial communities are one of the most important global challenges in daily life. Particularly the burden of implantable failure due to biofilm growth from bacteria resources has become a serious issue for dental or orthopedic implantable applications. To prevent suffering from bacterial resistance, increasing attention has been paid to protective antibacterial coatings on the surface. The protective coating of antimicrobial peptide (AMP) or antibiotics or nanoparticles on the surface of metal or polymeric substrates has been found to be effective against multiresistant bacteria, but also ecofriendly, biocompatible with living cells, and a promising implantable material.

Therefore, the purpose of this Special Issue is to explore the most recent progress in advanced functional antibacterial coatings to protect bactericidal effects for both Gram-positive and Gram-negative bacteria with cell compatibility. AMPs, antibiotics, nanoparticles, and biocompatible polymeric-type coatings on substrates could enhance surface properties and structural design and lead to promising antibacterial activities. Papers on all the potential applications in cell compatibility, cell proliferation, reactive oxygen species, membrane damage, structural deformation, etc., as well as the cell/bacterial structure–property relationships are welcome in this issue. Review papers and original research articles related to biocompatible coatings for antibacterial activities or biomedical applications are also welcome.

Dr. Selvaraj Rajesh Kumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial peptides
  • antibiotics
  • antibacterial activities
  • coatings
  • biofilm resistance
  • reactive oxygen species
  • implantable applications

Published Papers (5 papers)

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Research

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14 pages, 7234 KiB  
Article
Antimicrobial Peptide Conjugated on Graphene Oxide-Containing Sulfonated Polyetheretherketone Substrate for Effective Antibacterial Activities against Staphylococcus aureus
by Selvaraj Rajesh Kumar, Chih-Chien Hu, Truong Thi Tuong Vi, Dave W. Chen and Shingjiang Jessie Lue
Antibiotics 2023, 12(9), 1407; https://doi.org/10.3390/antibiotics12091407 - 05 Sep 2023
Cited by 1 | Viewed by 1019
Abstract
In the present study, the antimicrobial peptide nisin was successfully conjugated onto the surface of sulfonated polyetheretherketone (SPEEK), which was decorated with graphene oxide (GO) to investigate its biofilm resistance and antibacterial properties. The PEEK was activated with sulfuric acid, resulting in a [...] Read more.
In the present study, the antimicrobial peptide nisin was successfully conjugated onto the surface of sulfonated polyetheretherketone (SPEEK), which was decorated with graphene oxide (GO) to investigate its biofilm resistance and antibacterial properties. The PEEK was activated with sulfuric acid, resulting in a porous structure. The GO deposition fully covered the porous SPEEK specimen. The nisin conjugation was accomplished using the crosslinker 1–ethyl–3–(3–dimethylaminopropyl)carbodiimide (EDC) through a dip-coating method. The surface micrographs of the SPEEK-GO-nisin sample indicated that nisin formed discrete islets on the flat GO surface, allowing both the GO and nisin to perform a bactericidal effect. The developed materials were tested for bactericidal efficacy against Staphylococcus aureus (S. aureus). The SPEEK-GO-nisin sample had the highest antibacterial activity with an inhibition zone diameter of 27 mm, which was larger than those of the SPEEK-nisin (19 mm) and SPEEK-GO (10 mm) samples. Conversely, no inhibitory zone was observed for the PEEK and SPEEK samples. The surface micrographs of the bacteria-loaded SPEEK-GO-nisin sample demonstrated no bacterial adhesion and no biofilm formation. The SPEEK-nisin and SPEEK-GO samples showed some bacterial attachment, whereas the pure PEEK and SPEEK samples had abundant bacterial colonies and thick biofilm formation. These results confirmed the good biofilm resistance and antibacterial efficacy of the SPEEK-GO-nisin sample, which is promising for implantable orthopedic applications. Full article
(This article belongs to the Special Issue Development and Biomedical Application of Antibacterial Coatings)
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14 pages, 3633 KiB  
Article
Antibacterial and Antibiofilm Activity of Nanostructured Copper Films Prepared by Ionized Jet Deposition
by Daniele Ghezzi, Enrico Sassoni, Marco Boi, Matteo Montesissa, Nicola Baldini, Gabriela Graziani and Martina Cappelletti
Antibiotics 2023, 12(1), 55; https://doi.org/10.3390/antibiotics12010055 - 29 Dec 2022
Cited by 5 | Viewed by 1930
Abstract
Metal coatings represent good strategies to functionalize surfaces/devices and limit bacterial contamination/colonization thanks to their pleiotropic activity and their ability to prevent the biofilm formation. Here, we investigated the antibacterial and antibiofilm capacity of copper coatings deposited through the Ionized Jet Deposition (IJD) [...] Read more.
Metal coatings represent good strategies to functionalize surfaces/devices and limit bacterial contamination/colonization thanks to their pleiotropic activity and their ability to prevent the biofilm formation. Here, we investigated the antibacterial and antibiofilm capacity of copper coatings deposited through the Ionized Jet Deposition (IJD) on the Calgary Biofilm Device (CBD) against the growth of two gram-negative and two gram-positive pathogenic strains. Three areas (i.e., (+)Cu, (++)Cu, and (+++)Cu based on the metal amount) on the CBD were obtained, presenting nanostructured coatings with high surface homogeneity and increasing dimensions of aggregates from the CBD periphery to the centre. The coatings in (++)Cu and (+++)Cu were efficient against the planktonic growth of the four pathogens. This antibacterial effect decreased in (+)Cu but was still significant for most of the pathogens. The antibiofilm efficacy was significant for all the strains and on both coated and uncoated surfaces in (+++)Cu, whereas in (++)Cu the only biofilms forming on the coated surfaces were inhibited, suggesting that the decrease of the metal on the coatings was associated to a reduced metal ion release. In conclusion, this work demonstrates that Cu coatings deposited by IJD have antibacterial and antibiofilm activity against a broad range of pathogens indicating their possible application to functionalize biomedical devices. Full article
(This article belongs to the Special Issue Development and Biomedical Application of Antibacterial Coatings)
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Review

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38 pages, 8249 KiB  
Review
Atomic Layer Deposition of Antibacterial Nanocoatings: A Review
by Denis Nazarov, Lada Kozlova, Elizaveta Rogacheva, Ludmila Kraeva and Maxim Maximov
Antibiotics 2023, 12(12), 1656; https://doi.org/10.3390/antibiotics12121656 - 24 Nov 2023
Cited by 1 | Viewed by 1191
Abstract
In recent years, antibacterial coatings have become an important approach in the global fight against bacterial pathogens. Developments in materials science, chemistry, and biochemistry have led to a plethora of materials and chemical compounds that have the potential to create antibacterial coatings. However, [...] Read more.
In recent years, antibacterial coatings have become an important approach in the global fight against bacterial pathogens. Developments in materials science, chemistry, and biochemistry have led to a plethora of materials and chemical compounds that have the potential to create antibacterial coatings. However, insufficient attention has been paid to the analysis of the techniques and technologies used to apply these coatings. Among the various inorganic coating techniques, atomic layer deposition (ALD) is worthy of note. It enables the successful synthesis of high-purity inorganic nanocoatings on surfaces of complex shape and topography, while also providing precise control over their thickness and composition. ALD has various industrial applications, but its practical application in medicine is still limited. In recent years, a considerable number of papers have been published on the proposed use of thin films and coatings produced via ALD in medicine, notably those with antibacterial properties. The aim of this paper is to carefully evaluate and analyze the relevant literature on this topic. Simple oxide coatings, including TiO2, ZnO, Fe2O3, MgO, and ZrO2, were examined, as well as coatings containing metal nanoparticles such as Ag, Cu, Pt, and Au, and mixed systems such as TiO2-ZnO, TiO2-ZrO2, ZnO-Al2O3, TiO2-Ag, and ZnO-Ag. Through comparative analysis, we have been able to draw conclusions on the effectiveness of various antibacterial coatings of different compositions, including key characteristics such as thickness, morphology, and crystal structure. The use of ALD in the development of antibacterial coatings for various applications was analyzed. Furthermore, assumptions were made about the most promising areas of development. The final section provides a comparison of different coatings, as well as the advantages, disadvantages, and prospects of using ALD for the industrial production of antibacterial coatings. Full article
(This article belongs to the Special Issue Development and Biomedical Application of Antibacterial Coatings)
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19 pages, 3700 KiB  
Review
Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives
by S. Akshaya, Praveen Kumar Rowlo, Amey Dukle and A. Joseph Nathanael
Antibiotics 2022, 11(12), 1719; https://doi.org/10.3390/antibiotics11121719 - 29 Nov 2022
Cited by 31 | Viewed by 4264
Abstract
Titanium and its alloys are widely used as implant materials for biomedical devices owing to their high mechanical strength, biocompatibility, and corrosion resistance. However, there is a significant rise in implant-associated infections (IAIs) leading to revision surgeries, which are more complicated than the [...] Read more.
Titanium and its alloys are widely used as implant materials for biomedical devices owing to their high mechanical strength, biocompatibility, and corrosion resistance. However, there is a significant rise in implant-associated infections (IAIs) leading to revision surgeries, which are more complicated than the original replacement surgery. To reduce the risk of infections, numerous antibacterial agents, e.g., bioactive compounds, metal ions, nanoparticles, antimicrobial peptides, polymers, etc., have been incorporated on the surface of the titanium implant. Various coating methods and surface modification techniques, e.g., micro-arc oxidation (MAO), layer-by-layer (LbL) assembly, plasma electrolytic oxidation (PEO), anodization, magnetron sputtering, and spin coating, are exploited in the race to create a biocompatible, antibacterial titanium implant surface that can simultaneously promote tissue integration around the implant. The nature and surface morphology of implant coatings play an important role in bacterial inhibition and drug delivery. Surface modification of titanium implants with nanostructured materials, such as titanium nanotubes, enhances bone regeneration. Antimicrobial peptides loaded with antibiotics help to achieve sustained drug release and reduce the risk of antibiotic resistance. Additive manufacturing of patient-specific porous titanium implants will have a clear future direction in the development of antimicrobial titanium implants. In this review, a brief overview of the different types of coatings that are used to prevent implant-associated infections and the applications of 3D printing in the development of antibacterial titanium implants is presented. Full article
(This article belongs to the Special Issue Development and Biomedical Application of Antibacterial Coatings)
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18 pages, 3406 KiB  
Review
A Perspective on Newly Emerging Proteolysis-Targeting Strategies in Antimicrobial Drug Discovery
by Janarthanan Venkatesan, Dhanashree Murugan and Loganathan Rangasamy
Antibiotics 2022, 11(12), 1717; https://doi.org/10.3390/antibiotics11121717 - 29 Nov 2022
Cited by 5 | Viewed by 2447
Abstract
Targeted protein degradation is a new aspect in the field of drug discovery. Traditionally, developing an antibiotic includes tedious and expensive processes, such as drug screening, lead optimization, and formulation. Proteolysis-targeting chimeras (PROTACs) are new-generation drugs that use the proteolytic mechanism to selectively [...] Read more.
Targeted protein degradation is a new aspect in the field of drug discovery. Traditionally, developing an antibiotic includes tedious and expensive processes, such as drug screening, lead optimization, and formulation. Proteolysis-targeting chimeras (PROTACs) are new-generation drugs that use the proteolytic mechanism to selectively degrade and eliminate proteins involved in human diseases. The application of PROTACs is explored immensely in the field of cancer, and various PROTACs are in clinical trials. Thus, researchers have a profound interest in pursuing PROTAC technology as a new weapon to fight pathogenic viruses and bacteria. This review highlights the importance of antimicrobial PROTACs and other similar “PROTAC-like” techniques to degrade pathogenic target proteins (i.e., viral/bacterial proteins). These techniques can perform specific protein degradation of the pathogenic protein to avoid resistance caused by mutations or abnormal expression of the pathogenic protein. PROTAC-based antimicrobial therapeutics have the advantage of high specificity and the ability to degrade “undruggable” proteins, such as nonenzymatic and structural proteins. Full article
(This article belongs to the Special Issue Development and Biomedical Application of Antibacterial Coatings)
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