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Antibiotics
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Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic...
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Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic Derivatives of Natural Compounds on Pathogenic Microorganisms, 2nd Volume

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 4117

Special Issue Editors

Dr. Anna Duda-Madej

E-Mail Website
Guest Editor
Department of Microbiology, Faculty of Medicine, Wroclaw Medical University, Chałubińskiego 4, 50-368 Wrocław, Poland
Interests: flavonoid; natural compounds; biological activity; anticancer activity; antioxidant activity; chalcone; multidrug-resistant pathogens; food science; antimicrobial agents; cytotoxicity assays; amyloid; Crohn’s disease; AIEC; biofilm
Special Issues, Collections and Topics in MDPI journals
Dr. Joanna Kozłowska

E-Mail Website
Guest Editor
Department of Food Chemistry and Biocatalysis, The Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, Wrocław, Poland
Interests: flavonoids; plant extracts; natural compounds; biotransformations; antimicrobial activity; antitumor activity; antioxidant activity
Special Issues, Collections and Topics in MDPI journals
Dr. Katarzyna Wińska

E-Mail Website
Guest Editor
Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Interests: enzymatic catalysis; biotransformation; organic synthesis; isolation natural products; chemistry of cosmetic
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We have published one successful Special Issue “Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic Derivatives of Natural Compounds on Pathogenic Microorganisms https://www.mdpi.com/journal/antibiotics/special_issues/Plant_Antimi” This result encouraged us to produce a second volume on the same topic.

This second volume will include research and manuscripts regarding plant extracts and novel compounds, mainly of natural origin, characterized by strong biological activity. Research on alternative methods of obtaining new derivatives of natural origin are also welcome. Manuscripts that present the antimicrobial activity of natural compounds, including plant extracts, and chemical compounds commonly known to their synthetic derivatives will be appreciated. Manuscripts on the biological activity of natural extracts without proper chemical characterization will not be considered.

Dr. Anna Duda-Madej
Dr. Joanna Kozłowska
Dr. Katarzyna Wińska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial activity
  • plant extracts
  • plant-derived compounds
  • synthetic derivatives
  • flavonoids
  • multidrug resistance
  • pathogenic strains

Published Papers (3 papers)

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Research

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19 pages, 2597 KiB  
Article
Chemical Characterization and Biological Properties Assessment of Euphorbia resinifera and Euphorbia officinarum Moroccan Propolis
by Oumaima Boutoub, Soukaina El-Guendouz, Isabel Matos, Lahsen El Ghadraoui, Maria Clara Costa, Jorge Dias Carlier, Maria Leonor Faleiro, Ana Cristina Figueiredo, Letícia M. Estevinho and Maria Graça Miguel
Antibiotics 2024, 13(3), 230; https://doi.org/10.3390/antibiotics13030230 - 29 Feb 2024
Viewed by 995
Abstract
Although the plants of the genus Euphorbia are largely exploited by therapists in Morocco, the composition and antibacterial activities of propolis from these plants are still unknown. To address this gap, this study aimed to characterize the pollen type, the volatile compounds, and [...] Read more.
Although the plants of the genus Euphorbia are largely exploited by therapists in Morocco, the composition and antibacterial activities of propolis from these plants are still unknown. To address this gap, this study aimed to characterize the pollen type, the volatile compounds, and the phenolic and mineral profiles of three Euphorbia propolis samples collected in Morocco and evaluate their antimicrobial activities. The minimum inhibitory concentration of the propolis samples was determined by the microdilution method, and the anti-adherence activity was evaluated by the crystal violet assay. The examination of anti-quorum-sensing proprieties was performed using the biosensor Chromobacterium violaceum CV026. Pollen analysis revealed that Euphorbia resinifera pollen dominated in the P1 sample (58%), while E. officinarum pollen dominated in the P2 and P3 samples (44%). The volatile compounds were primarily composed of monoterpene hydrocarbons, constituting 35% in P1 and 31% in P2, with α-pinene being the major component in both cases, at 16% in P1 and 15% in P2. Calcium (Ca) was the predominant mineral element in both E. resinifera (P1) and E. officinarum (P2 and P3) propolis samples. Higher levels of phenols, flavonoids and dihydroflavonoids were detected in the E. officinarum P2 sample. The minimum inhibitory concentration (MIC) value ranged from 50 to 450 µL/mL against Gram-positive and Gram-negative bacteria. Euphorbia propolis displayed the ability to inhibit quorum sensing in the biosensor C. violaceum CV026 and disrupted bacterial biofilm formation, including that of resistant bacterial pathogens. In summary, the current study evidences the potential use of E. officinarum propolis (P2 and P3) to combat important features of resistant pathogenic bacteria, such as quorum sensing and biofilm formation. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic Derivatives of Natural Compounds on Pathogenic Microorganisms, 2nd Volume)
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22 pages, 3437 KiB  
Article
Candida krusei M4CK Produces a Bioemulsifier That Acts on Melaleuca Essential Oil and Aids in Its Antibacterial and Antibiofilm Activity
by Jéssica Mayra Mendes Araujo, Joveliane Melo Monteiro, Douglas Henrique dos Santos Silva, Amanda Karoline Veira, Maria Raimunda Chagas Silva, Fernanda Avelino Ferraz, Fábio H. Ramos Braga, Ezequias Pessoa de Siqueira and Andrea de Souza Monteiro
Antibiotics 2023, 12(12), 1686; https://doi.org/10.3390/antibiotics12121686 - 30 Nov 2023
Viewed by 917
Abstract
Surface-active compounds (SACs) of microbial origin are an active group of biomolecules with potential use in the formulation of emulsions. In this sense, the present study aimed to isolate and select yeasts from fruits that could produce SACs for essential oil emulsions. The [...] Read more.
Surface-active compounds (SACs) of microbial origin are an active group of biomolecules with potential use in the formulation of emulsions. In this sense, the present study aimed to isolate and select yeasts from fruits that could produce SACs for essential oil emulsions. The Candida krusei M4CK was isolated from the Byrsonima crassifolia fruit to make SACs. This emulsification activity (E24) was equal to or greater 50% in all carbon sources, such as olive oil, sunflower oil, kerosene, hexane, and hexadecane. E24 followed exponential growth according to the growth phase. The stability of emulsions was maintained over a wide range of temperatures, pH, and salinity. The OMBE4CK (melaleuca essential oil emulsion) had better and more significant inhibitory potential for biofilm reduction formation. In addition, bioemulsifier BE4CK alone on Escherichia coli and Pseudomonas aeruginosa biofilm showed few effective results, while there was a significant eradication for Staphylococcus aureus biofilms. The biofilms formed by S. aureus were eradicated in all concentrations of OMBE4CK. At the same time, the preformed biofilm by E. coli and P. aeruginosa were removed entirely at concentrations of 25 mg/mL, 12.5 mg/mL, and 6.25 mg/mL. The results show that the bioemulsifier BE4CK may represent a new potential for antibiofilm application. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic Derivatives of Natural Compounds on Pathogenic Microorganisms, 2nd Volume)
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Review

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17 pages, 636 KiB  
Review
Meropenem/Vaborbactam: β-Lactam/β-Lactamase Inhibitor Combination, the Future in Eradicating Multidrug Resistance
by Anna Duda-Madej, Szymon Viscardi and Ewa Topola
Antibiotics 2023, 12(11), 1612; https://doi.org/10.3390/antibiotics12111612 - 10 Nov 2023
Cited by 3 | Viewed by 1516
Abstract
Due to the fact that there is a steadily increasing trend in the area of antimicrobial resistance in microorganisms, there is a need to look for new treatment alternatives. One of them is the search for new β-lactamase inhibitors and combining them with [...] Read more.
Due to the fact that there is a steadily increasing trend in the area of antimicrobial resistance in microorganisms, there is a need to look for new treatment alternatives. One of them is the search for new β-lactamase inhibitors and combining them with β-lactam antibiotics, with the aim of increasing the low-dose efficacy, as well as lowering the resistance potential of bacterial strains. This review presents the positive effect of meropenem in combination with a vaborbactam (MER-VAB). This latest antibiotic-inhibitor combination has found particular use in the treatment of infections with the etiology of carbapenem-resistant Enterobacterales (CRE), Gram-negative bacteria, with a high degree of resistance to available antimicrobial drugs. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic Derivatives of Natural Compounds on Pathogenic Microorganisms, 2nd Volume)
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