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Antibiotics
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The Application of Antibiotic Therapy in Oral Surgery and Dental...
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The Application of Antibiotic Therapy in Oral Surgery and Dental Implant Procedures

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 10942

Special Issue Editors

Prof. Dr. Eugenio Velasco-Ortega

E-Mail Website
Guest Editor
Department of Comprehensive Dentistry. Master in Implant Dentistry. School of Dentistry, University of Seville, 41009 Seville, Spain
Interests: oral implantology; dental implantology; dental implants; dentistry
Special Issues, Collections and Topics in MDPI journals
Dr. Angel-Orion Salgado-Peralvo

E-Mail Website
Guest Editor
Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain
Interests: antibiotics; preventive antibiotic therapy; antibiotic prophylaxis; bacterial antibiotic resistance; antibiotic resistance; oral implantology; dental implantology; dental implants; dentistry
Dr. Juan Francisco Peña-Cardelles

E-Mail Website
Guest Editor
1. Oral and Maxillofacial Surgery Department, University of Connecticut, Storrs, CT, USA
2. Prosthodontics Department, University of Connecticut, Storrs, CT, USA
3. Oral Surgery and Implantology Program, Universidad Rey Juan Carlos, Madrid, Spain
Interests: oral surgery; oral medicine; oral implantology

Special Issue Information

Dear Colleagues,

The presence of more than 300 bacterial species at the oral level may contribute to the occurrence of postoperative infections. The prescribing of antimicrobials is conventional in oral implantology and oral surgery procedures not only to avoid systemic bacteremia, but also to reach an adequate antibiotic concentration in the blood with the goal of preventing bacterial contamination during surgeries involving implants or grafted material. In spite of recent advances in this field, there currently is still a lack of sufficient high-quality investigations.

This Special Issue of Antibiotics deals with these topics. The issue welcomes original research papers, short communications, reviews, case reports, and perspectives.

Potential topics for this Special Issue include but are not limited to:

  • Protocols in dental implant procedures.
  • Protocols in oral surgery procedures.
  • Microbiology concerning dental implant failures and/or peri-implantitis.
  • Microbiology concerning oral surgery procedures.
  • Epidemiology of antibiotic-resistant species.
  • New therapies in preventive antibiotic therapy and/or antibiotic prophylaxis.
  • Prescription patterns of professionals dedicated to oral surgery and oral implantology.

Prof. Dr. Eugenio Velasco-Ortega
Dr. Angel-Orion Salgado-Peralvo
Dr. Juan Francisco Peña-Cardelles
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotics
  • preventive antibiotic therapy
  • antibiotic prophylaxis
  • bacterial antibiotic resistance
  • antibiotic resistance
  • oral implantology
  • dental implantology
  • dental implants
  • dentistry
  • oral surgery

Published Papers (5 papers)

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Research

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18 pages, 7223 KiB  
Article
A Single Dose of Piperacillin Plus Tazobactam Gel as an Adjunct to Professional Mechanical Plaque Removal (PMPR) in Patients with Peri-Implant Mucositis: A 6-Month Double-Blind Randomized Clinical Trial
by Ioana Ilyes, Marius Boariu, Darian Rusu, Vincenzo Iorio-Siciliano, Octavia Vela, Simina Boia, Georgios Kardaras, Petra Șurlin, Horia Calniceanu, Holger Jentsch, Alexandru Lodin and Stefan-Ioan Stratul
Antibiotics 2024, 13(3), 269; https://doi.org/10.3390/antibiotics13030269 - 17 Mar 2024
Viewed by 921
Abstract
Objectives: This randomized, placebo-controlled, double-masked clinical trial aimed to evaluate the clinical and microbiological efficacy of professional mechanical plaque removal (PMPR) with or without adjunctive application of piperacillin plus tazobactam gel in the treatment of peri-implant mucositis (PiM) for up to 6 months. [...] Read more.
Objectives: This randomized, placebo-controlled, double-masked clinical trial aimed to evaluate the clinical and microbiological efficacy of professional mechanical plaque removal (PMPR) with or without adjunctive application of piperacillin plus tazobactam gel in the treatment of peri-implant mucositis (PiM) for up to 6 months. Materials and Methods: The study included 31 patients with peri-implant mucositis (bleeding on probing (BoP) > 1 at at least one site at baseline, absence of peri-implant bone loss compared with a previous radiograph). After randomized assignment to test and control groups, patients received full-mouth supragingival scaling with or without piperacillin plus tazobactam gel. Clinical examination was performed at baseline and after 3 and 6 months, and a microbiological examination was performed at baseline and after 3 months. Results: After six months, both treatment modalities resulted in significant reductions and improvements in clinical parameters at the implant sites. Neither study group achieved a complete resolution of PiM (i.e., BoP ≤ 1 per implant). The number of implants with BoP decreased statistically significantly between subsequent time points (p < 0.001) in both the test and the control group. Significant BoP differences (p = 0.039) were observed between groups at 6 months (difference to baseline) following therapy. Conclusions: Within the limitations of the present study, the single use of a slow-release, locally applied antibiotic combination of piperacillin and tazobactam gel, adjunctive to PMPR, showed an improvement in clinical variable of implants diagnosed with PiM. The adjunctive treatment resulted in higher BoP reduction when compared to the control, but no significant differences were observed regarding the changes in other clinical and microbiological parameters. Full article
(This article belongs to the Special Issue The Application of Antibiotic Therapy in Oral Surgery and Dental Implant Procedures)
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17 pages, 5051 KiB  
Article
Study on Optimizing Novel Antimicrobial Peptides with Bifunctional Activity to Prevent and Treat Peri-Implant Disease
by Shuipeng Yu, Qian Zhang, Meilin Hu, Borui Zhao, Zhiyang Liu, Changyi Li and Xi Zhang
Antibiotics 2022, 11(11), 1482; https://doi.org/10.3390/antibiotics11111482 - 26 Oct 2022
Cited by 2 | Viewed by 1398
Abstract
The bacterial invasions and inflammatory responses after implant placement often affect osseointegration; the increased secretion of pro-inflammatory cytokines can lead to poor formation of bone and bone absorption. Previous research has shown that the antimicrobial peptide 6K-F17 has antibacterial and immunomodulatory properties. The [...] Read more.
The bacterial invasions and inflammatory responses after implant placement often affect osseointegration; the increased secretion of pro-inflammatory cytokines can lead to poor formation of bone and bone absorption. Previous research has shown that the antimicrobial peptide 6K-F17 has antibacterial and immunomodulatory properties. The objective of this study was to optimize KR−1 and KR−2, based on 6K-F17, to apply to the tissue around the oral implant. Our first objective is to study its antibacterial properties, and then we intend to further study its osteogenic ability to osteoblasts by modulating the immune response of macrophages. In this research, KR−1 and KR−2 can inhibit the formation of bacterial biofilm, and further kill bacteria S. gordonii and F. nucleatum by destroying the cell wall and cell membrane of bacteria. The novel peptides restrained the activation of the NF-κB signaling pathway by reducing the phosphorylation levels of IκBα and p65, inhibiting the degradation of IκBα and the nuclear translocation of p65, and increasing the percentage of M2 phenotype in macrophages. This suppressed the inflammatory response induced by lipopolysaccharides and enhanced the osteogenic activity of osteoblasts; this, in turn, promoted osteogenesis. The antimicrobial peptide KR−1 showed better performance. Our results demonstrate that KR−1 and KR−2 have antibacterial and bone immunomodulatory effects, and further promote osteogenesis by modulating the immune microenvironment, which provides the possibility for the adjuvant treatment of peri-implant diseases. Full article
(This article belongs to the Special Issue The Application of Antibiotic Therapy in Oral Surgery and Dental Implant Procedures)
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17 pages, 328 KiB  
Communication
Consensus Report on Preventive Antibiotic Therapy in Dental Implant Procedures: Summary of Recommendations from the Spanish Society of Implants
by Angel-Orión Salgado-Peralvo, Alvaro Garcia-Sanchez, Naresh Kewalramani, Antonio Barone, Jose-María Martínez-González, Eugenio Velasco-Ortega, José López-López, Rodrigo Kaiser-Cifuentes, Fernando Guerra, Nuno Matos-Garrido, Jesús Moreno-Muñoz, Enrique Núñez-Márquez, Iván Ortiz-García, Álvaro Jiménez-Guerra and Loreto Monsalve-Guil
Antibiotics 2022, 11(5), 655; https://doi.org/10.3390/antibiotics11050655 - 13 May 2022
Cited by 8 | Viewed by 4314
Abstract
Current patterns of preventive antibiotic prescribing are encouraging the spread of antimicrobial resistance. Recently, the Spanish Society of Implants (SEI) developed the first clinical practice guidelines published to date, providing clear guidelines on how to prescribe responsible and informed preventive antibiotic therapy (PAT) [...] Read more.
Current patterns of preventive antibiotic prescribing are encouraging the spread of antimicrobial resistance. Recently, the Spanish Society of Implants (SEI) developed the first clinical practice guidelines published to date, providing clear guidelines on how to prescribe responsible and informed preventive antibiotic therapy (PAT) based on the available scientific evidence on dental implant treatments (DIs). The present document aims to summarise and disseminate the recommendations established by this expert panel. These were based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were analysed using the Scottish Intercollegiate Guidelines Network (SIGN) checklist templates and ranked according to their level of evidence. They were then assigned a level of recommendation using the Grading of Recommendations, Assessment, Development and Evaluation system (GRADE). Guidelines were established on the type of PAT, antibiotic and dosage of administration in the placement of DIs without anatomical constraints, in bone augmentation with the placement of DIs in one or two stages, placement of immediate DIs, sinus elevations, implant prosthetic phase, as well as recommendations in patients allergic to penicillin. Therefore, the PAT must be adapted to the type of implant procedure to be performed. Full article
(This article belongs to the Special Issue The Application of Antibiotic Therapy in Oral Surgery and Dental Implant Procedures)

Other

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19 pages, 4340 KiB  
Systematic Review
A Systematic Review and Meta-Analysis of Systemic and Local Antibiotic Therapy in the Surgical Treatment of Peri-Implantitis
by María Baus-Domínguez, Sara Bakkali, Paula Hermida-Cabrera, María-Angeles Serrera-Figallo, José-Luis Gutiérrez-Pérez and Daniel Torres-Lagares
Antibiotics 2023, 12(7), 1223; https://doi.org/10.3390/antibiotics12071223 - 24 Jul 2023
Cited by 1 | Viewed by 1442
Abstract
(1) Background: Given the existing controversy regarding the use of antibiotics in the treatment of peri-implantitis, this systematic review and meta-analysis aim to ascertain how beneficial the role of systemic and local antibiotics is in peri-implant surgical therapy, considering the harmful effects that [...] Read more.
(1) Background: Given the existing controversy regarding the use of antibiotics in the treatment of peri-implantitis, this systematic review and meta-analysis aim to ascertain how beneficial the role of systemic and local antibiotics is in peri-implant surgical therapy, considering the harmful effects that they represent and the abuse of antibiotics in terms of global health. (2) Methods: To determine the therapeutic efficacy of the administration of antibiotics in the surgical treatment of peri-implantitis in terms of probing pocket depth (PPD) and bleeding on probing (BoP), electronic and manual bibliographic searches were carried out in the Embase and PubMed databases, collecting data that related to before and after treatment. (3) Results: The adjunctive use of local antibiotics provides significant improvements in PPD (MD = 1.29; 95% CI: 0.56 to 2.02; p ≤ 0.0006; I2 = 0%) when compared with surgical treatment alone. No significant differences were found in the other subgroup; that is, the use of systemic antibiotics did not significantly improve PPD changes in the surgical treatment of peri-implantitis (MD = 0.40; 95% CI: −0.15 to 0.95; p = 0.15; I2 = 0). (4) Conclusions: The use of local antibiotics in the surgical treatment of peri-implantitis seems to offer treatment improvements in terms of PPD and BoP, unlike that observed with the use of systemic antibiotics. However, these results should be taken with caution as they also depend on the type of surgical technique used, whether regenerative or resective. More research is needed on this topic to understand the role of local and systemic antibiotics in the treatment of peri-implantitis. Full article
(This article belongs to the Special Issue The Application of Antibiotic Therapy in Oral Surgery and Dental Implant Procedures)
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16 pages, 1386 KiB  
Systematic Review
Comparative Efficacy of Different Amoxicillin Dosing Regimens in Preventing Early Implant Failure—A Systematic Review with Network Meta-Analysis
by Lee Wen Tan, Yan Er Ng, Koay Chun Giok, Sajesh K. Veettil and Rohit Kunnath Menon
Antibiotics 2023, 12(3), 512; https://doi.org/10.3390/antibiotics12030512 - 03 Mar 2023
Cited by 3 | Viewed by 1736
Abstract
This systematic review and network meta-analysis aimed to assess the comparative efficacy and safety of antibiotics to prevent early implant failure in patients undergoing dental implant surgery. Methods: The review was registered in PROSPERO [CRD42022319385]. A search was conducted for trials published in [...] Read more.
This systematic review and network meta-analysis aimed to assess the comparative efficacy and safety of antibiotics to prevent early implant failure in patients undergoing dental implant surgery. Methods: The review was registered in PROSPERO [CRD42022319385]. A search was conducted for trials published in Medline, Cochrane, PubMed, and Scopus. A network meta-analysis was performed on the data from randomized controlled trials. Agents were ranked according to their effectiveness based on outcomes (implant failure, prosthetic failure, postsurgical complications, and adverse effects) using the surface under the cumulative ranking [SUCRA]. Results: A total of 15 articles were included in the quantitative analysis. When compared to the placebo, 2 g of amoxicillin given 1 h preoperatively (RR = 0.42 (95%CI: 0.27, 0.67)), 2 g of amoxicillin given 1 h preoperatively with postoperative 500 mg thrice for 5 days (RR = 0.36 (95%CI: 0.15, 0.87)), and post-operative amoxicillin with clavulanic acid 625 mg 3 times daily for 5 days (RR = 0.38 (95%CI: 0.16, 0.90)) were effective in reducing early implant failures. In addition, 2 g of amoxicillin given 1 h preoperatively (RR = 0.42 (95%CI: 0.25, 0.73)) was the only protocol that was significant in the pairwise meta-analysis results. However, sensitivity analysis, which excluded trials with a high risk of bias, showed that none of the protocols were statistically significant in reducing early implant failure. Conclusions: A single 2 g dose of preoperative amoxicillin significantly reduces early implant failure in healthy individuals. More high-quality trials are required to establish this recommendation, as the quality of this evidence is weak. Full article
(This article belongs to the Special Issue The Application of Antibiotic Therapy in Oral Surgery and Dental Implant Procedures)
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