Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.5
4.8
Journals
Antibiotics
Special Issues
Antibiotic Treatment in Dermatology
share announcement

Antibiotic Treatment in Dermatology

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 17795

Special Issue Editors

Dr. Ayman Grada

E-Mail
Guest Editor
Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Interests: medical dermatology; skin infections; antibiotics; chronic wounds; acne vulgaris; atopic dermatitis; drug development
Special Issues, Collections and Topics in MDPI journals
Dr. Christopher Bunick

E-Mail Website
Guest Editor
Department of Dermatology, Yale School of Medicine, New Haven, CT, USA
Interests: medical dermatology; antibiotics; skin infections; biochemistry; biophysics; dermatitis; atopic; dermatology; epidermis; intermediate filaments; keratins; molecular biology; skin; ichthyosis vulgaris; crystallography; X-ray; computational biology; proteomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antibiotics have been and continue to be used extensively in dermatology. Both topical and systemic antibiotics have been used in skin conditions ranging from cutaneous infections such as impetigo and cellulitis, to acne and rosacea, to inflammatory dermatoses such as hidradenitis suppurativa, bullous pemphigoid, and neutrophilic dermatoses, and also surgical prophylaxis and wound healing. Antibiotics are generally categorized as either broad-spectrum or narrow-spectrum antibiotics according to their spectrum of antimicrobial activity. Broad-spectrum antibiotics, such as amoxicillin and clavulanic acid, azithromycin, doxycycline, fluoroquinolones, minocycline, and mupirocin, target a wide range of Gram-positive and Gram-negative bacteria, whereas narrow-spectrum antibiotics, such as fidaxomicin, sarecycline, and vancomycin, only target limited types of clinically relevant bacteria. Moreover, based on their mechanism of action, antibiotics have been classified into bactericidal (i.e., they kill bacteria) and bacteriostatic (i.e., they only inhibit the growth or proliferation of bacteria) categories. For example, tetracyclines are generally considered bacteriostatic, whereas fluoroquinolones are bactericidal.

Dermatologists prescribe more oral antibiotic courses per clinician than any other specialty, and many of these courses of antibiotics are prescribed for several months in duration. The prolonged and intermittent use of broad-spectrum antibiotics has been associated with the development of antimicrobial resistance and permanent perturbation of the human microbiome. Sub-antimicrobial doses of doxycycline have been used in acne and rosacea. However, recent evidence suggests that sub-minimum inhibitory concentrations (MICs) of antibiotics can select for resistant bacteria through various mechanisms. Clinical consequences of antibiotic resistance include reduced treatment effectiveness and transmission of resistance to other bacteria.

Broad-spectrum tetracycline-class antibiotics (doxycycline and minocycline) are the most prescribed by dermatologists, accounting for almost 70% of antibiotic prescriptions by dermatologists. The median duration of therapy with oral antibiotics is around 4 months among patients managed by dermatologists. 

This Special Issue titled “Antibiotic Treatment in Dermatology” will focus on the utility of antibiotics to treat skin disease, current trends, the impact of broad-spectrum antibiotics on the microbiome and resistance, unmet needs for narrow-spectrum antibiotics, antibiotic stewardship, and future directions. We kindly invite original research articles as well as commentaries and review papers. All articles will be peer reviewed.

Dr. Ayman Grada
Dr. Christopher G Bunick
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotics
  • tetracyclines
  • skin infection
  • acne
  • rosacea
  • inflammation
  • dermatology
  • narrow-spectrum antibiotics

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

Jump to: Other

11 pages, 291 KiB  
Review
Oral Tetracycline-Class Drugs in Dermatology: Impact of Food Intake on Absorption and Efficacy
by Rachel E. Tao, Stuti Prajapati, Jessica N. Pixley, Ayman Grada and Steven R. Feldman
Antibiotics 2023, 12(7), 1152; https://doi.org/10.3390/antibiotics12071152 - 5 Jul 2023
Cited by 4 | Viewed by 1904
Abstract
Tetracycline-class drugs are frequently used in dermatology for their anti-inflammatory properties to treat skin diseases such as acne, rosacea, and hidradenitis suppurativa (HS). The American Academy of Dermatology (AAD) clinical guidelines do not offer guidance regarding the co-administration of food with tetracycline-class drugs. [...] Read more.
Tetracycline-class drugs are frequently used in dermatology for their anti-inflammatory properties to treat skin diseases such as acne, rosacea, and hidradenitis suppurativa (HS). The American Academy of Dermatology (AAD) clinical guidelines do not offer guidance regarding the co-administration of food with tetracycline-class drugs. The objectives of this study were to review the available evidence regarding whether taking tetracycline-class drugs with food decreases systemic absorption and is associated with an impact on clinical efficacy. A literature search was conducted using the PubMed database between February to May 2023 using the keywords “tetracycline-class drugs”, “pharmacokinetics”, “absorption”, and “dermatology”. Inclusion criteria included articles written in English and relevant to the absorption and efficacy of tetracycline-class drugs. This search yielded 131 articles written between 1977 to 2022, of which 29 met the criteria for review. United States Food and Drug Administration (FDA)-approved prescribing information for oral formulations of tetracycline, doxycycline, minocycline, and sarecycline were reviewed. Systemic absorption of tetracycline decreased when co-administered with food. Systemic absorption of oral doxycycline and minocycline was variable with food co-administration. The impact on bioavailability varied with the drug formulation and dosage. The absorption of oral sarecycline decreased when administered with food. Sarecycline is the only oral antibiotic where population pharmacokinetic studies demonstrated limited or no impact of food intake on clinical efficacy. There are no available data for other tetracycline-class drugs in dermatology. If patients find it more tolerable to take doxycycline, minocycline, and sarecycline with food to avoid gastrointestinal distress, this may merit consideration to encourage patient adherence. Since the impact of food intake on absorption varied with the dosage form of doxycycline and minocycline, consulting the appropriate package insert may give clinicians additional insight into differences in the various formulations. Full article
(This article belongs to the Special Issue Antibiotic Treatment in Dermatology)
13 pages, 459 KiB  
Review
Topical Antibiotic Treatment in Dermatology
by Matthew Dallo, Kavina Patel and Adelaide A. Hebert
Antibiotics 2023, 12(2), 188; https://doi.org/10.3390/antibiotics12020188 - 17 Jan 2023
Cited by 7 | Viewed by 9243
Abstract
Many indications in dermatology can be effectively managed with topical antibiotics, including acne vulgaris, wound infections, secondarily infected dermatitis, and impetigo. Dermatologists must be familiar with the wide spectrum of topical antibiotics available, including indications, mechanisms of action, adverse events, and spectra of [...] Read more.
Many indications in dermatology can be effectively managed with topical antibiotics, including acne vulgaris, wound infections, secondarily infected dermatitis, and impetigo. Dermatologists must be familiar with the wide spectrum of topical antibiotics available, including indications, mechanisms of action, adverse events, and spectra of activity. Dermatologists must also keep antibiotic resistance in mind when utilizing these medications. Due to the widespread use of topical antibiotics and their importance in dermatology, a literature review was performed using a systematic search of PubMed and Google Scholar with the terms topical antibiotics, skin infections, dermatology, antimicrobials, and inflammatory dermatoses to identify English-language articles published between 1965–2022 from any country. Relevant publications were manually reviewed for additional content. The following literature review will summarize the common topical antibiotics used in dermatology. Full article
(This article belongs to the Special Issue Antibiotic Treatment in Dermatology)
►▼ Show Figures

Figure 1

Other

Jump to: Review

17 pages, 1635 KiB  
Systematic Review
Microbiomes in Acne Vulgaris and Their Susceptibility to Antibiotics in Indonesia: A Systematic Review and Meta-Analysis
by Lili Legiawati, Paulus Anthony Halim, Magna Fitriani, Hardya Gustada Hikmahrachim and Henry W. Lim
Antibiotics 2023, 12(1), 145; https://doi.org/10.3390/antibiotics12010145 - 11 Jan 2023
Cited by 5 | Viewed by 4287
Abstract
Hot and humid countries such as Indonesia have a higher prevalence of acne vulgaris (AV). The activity of skin microbes, not only Cutibacterium acnes, contribute to the formation of AV. Topical and oral antibiotics are routinely prescribed to treat AV. As antimicrobial [...] Read more.
Hot and humid countries such as Indonesia have a higher prevalence of acne vulgaris (AV). The activity of skin microbes, not only Cutibacterium acnes, contribute to the formation of AV. Topical and oral antibiotics are routinely prescribed to treat AV. As antimicrobial resistance rates increase globally, there are concerns about decreased efficacy. This study intends to systematically evaluate the microbiomes isolated from AV lesions and their antibiotics susceptibility in Indonesia. The data were retrieved through PubMed, EMBASE, Google Scholar, and ScienceDirect searches for articles published until July 2022 using three multiword searches. Sixteen studies published between 2001 and 2022 were identified from which the data were pooled using a random effects model. The pooled prevalence estimates demonstrated that C. acnes, Staphylococcus epidermidis, and Staphylococcus aureus were the three common microbes associated with AV in Indonesia. Tetracyclines had lower resistance rates compared to those of macrolides and clindamycin, with C. acnes showing a resistance rate that is as high as 60.1% against macrolides. C. acnes resistance against minocycline showed an increasing trend, whereas the resistances to doxycycline, clindamycin, and macrolides stagnated. The high resistance prevalence and trends signify a public health concern. The results of this study call for the development of antibiotic stewardship programs in Indonesia, which may lead to improved acne outcomes. Full article
(This article belongs to the Special Issue Antibiotic Treatment in Dermatology)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop