Oxidative Stress and Antioxidants in Neurodegenerative Disorders 2nd Edition
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 15648
Special Issue Editor
Interests: iron homeostasis; neurodegenerative diseases; multi-target drugs; reactive oxygen species; iron/calcium interaction in the nervous system; intestinal iron absorption
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Growing evidence has indicated that oxidative stress, mitochondria dysfunction, inflammation, lysosomal dysfunction, protein aggregation and iron deposition are key factors leading to neuronal death in neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease and a heterogeneous group of disorders known as neurodegeneration with brain iron accumulation. Increasingly, it has been acknowledged that several of these factors are intertwined, generating positive feed-back loops that conclude in neuronal dysfunction and death.
Reactive oxygen species are central in these positive loops, since they contribute to mitochondria dysfunction and, together with iron, to lipid peroxidation and ferroptosis.
Antioxidants, in particular lipophilic antioxidants, are of clinical interest, since they have the potential to stop the lipid peroxidation cycle iniciated by the hydroxyl radical, as well as protein aggregation and nucleic acid damage.
The understanding of how these different players, manely, oxidative stress, protein aggregation, mitochondrial dysfunction and inflammation interact to generate neurodegeneration is an open field of enormous importance. Equally relevant is the design of therapeutic strategies based in the abrogation of positive feed-back loops that leed to neuronal death. In the design of these strategies, antioxidants, iron chelators and anti-inflammatory effectors are most important participants.
Prof. Dr. Marco Tulio Núñez
Guest Editor
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Keywords
- neurodegenerative diseases, oxidative stress
- antioxidants
- ferroptosis
- mitochondria dysfuction
- protein aggregation
- inflammation
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