Oxidative Stress and Neuroinflammation in Neurodegenerative Diseases: Mechanisms and Therapies
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 7912
Special Issue Editors
2. Networking Research Center on Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain
Interests: Parkinson's disease; dyskinesia; neurodegeneration; oxidative stress; neuroinflammation; neuroprotection
2. Networking Research Center on Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain
Interests: neuroscience; neurodegeneration; neuroprotection; cell therapy; Parkinson's disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are the leading causes of disability and dependency, and the second leading cause of mortality worldwide. With the increase in life expectancy, the incidence of neurodegenerative diseases and their global socioeconomic impact has increased considerably in recent years and is expected to increase further in the coming decades. Aging is one of the main risk factors for these diseases, accelerating the cellular death process. It has been described that different neurodegenerative diseases have common mechanisms underlying neuronal death, even when the symptoms and the areas of the nervous system affected are different. Oxidative stress and chronic neuroinflammation are common pathological mechanisms in diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis. Microglia activation could induce the release of cytokines and an upregulated production of reactive oxygen species leading to mitochondrial dysfunction and neuronal death. Nevertheless, the mechanisms involved in the different diseases are not fully understood. Consistent with this, strategies modulating oxidative stress and neuroinflammatory pathways are proposed as effective therapies to counteract the progression of neurodegeneration, and numerous assays in experimental models and clinical trials are carried out. However, there is still no effective therapy for these diseases, and many issues should be addressed.
This Special Issue aims to publish original research studies or reviews to broaden the knowledge of the mechanisms related to oxidative stress and neuroinflammation in neurodegenerative diseases to develop new therapeutical approaches targeting these pathways.
We invite you to submit your contribution to this Special Issue, and we are highly grateful to receive your manuscripts.
Prof. Dr. Ana M. Munoz
Dr. Jannette Rodríguez-Pallares
Guest Editors
Manuscript Submission Information
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Keywords
- neurodegeneration
- aging
- neuroprotection
- mitochondrial dysfunction
- cytokines
- apoptosis
- autophagy
- microglia
- astroglia
- antioxidants
- free radicals
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