Hormones and Oxidative Stress
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 October 2024) | Viewed by 1098
Special Issue Editor
Special Issue Information
Dear Colleagues,
Reactive oxygen species (ROS) are generated as normal products of aerobic cellular metabolism. ROS produced at low concentrations have beneficial effects on a variety of physiological processes, including cellular signaling, proliferation, and growth. However, when present at high levels, ROS can react with lipids, proteins, and DNA, causing cell damage with consequent biochemical and biophysical deleterious effects. Therefore, all aerobic organisms have evolved both enzymatic and nonenzymatic antioxidant defense mechanisms to counteract the deleterious impact of ROS on cells and tissues. An imbalance between the production of ROS and the capability of the antioxidant defense system results in the induction of oxidative stress, which is involved in different pathological events, including cardiovascular disease, obesity, diabetes, and cancer. The regulation of cellular antioxidant defenses may be influenced by different factors, such as age, organ specificity, and hormonal state. Some hormones, such as melatonin, insulin, and estrogen, act as antioxidants and/or exert an impact on the various enzymatic and non-enzymatic components of the defense system, while others, including thyroid hormones, corticosteroids, and catecholamines, promote the generation of ROS and oxidative stress. Moreover, any alterations in the hormonal milieu can exhibit significant effects on ROS production and oxidative stress, possibly leading to pathological conditions. The intricate interplay between the endocrine system, redox equilibrium, and oxidative stress is a topic that deserves to be elucidated given its potential impact on human health.
For this Special Issue, “Hormones and Oxidative Stress”, we invite you to submit your original research papers and reviews with the aim of better understanding the complex relationship between hormonal conditions, redox states, and oxidative stress in living systems in both physiological and pathological conditions.
Dr. Silvia Nistri
Guest Editor
Manuscript Submission Information
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Keywords
- reactive oxygen species
- oxidative stress
- hormones
- antioxidants
- melatonin
- insulin
- estrogen
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