Antioxidant and Anti-inflammatory Potential of Plants in Cancer Treatment

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 2406

Special Issue Editors


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Guest Editor
Faculté de Pharmacie de Paris, Université Paris Cité, U.M.R. n°8038-CiTCoM-(CNRS, Université de Paris Cité), F-75006 Paris, France
Interests: natural products chemistry; pharmacognosy; semisynthesis
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Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, Edificio Polifunzionale, 87036 Arcavacata Rende, CS, Italy
Interests: natural products; antioxidants; chemical analysis; Mediterranean species; plant bioactivities; agro-food by-products; enzymes inhibition; functional foods
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Wild or cultivated plants, whether edible or medicinal, are valuable sources of bioactive compounds such as polyphenols, organic acids, non-volatile terpenoids, steroids, alkaloids, and their glycosides. Polyphenols being the most common, many applications of plant extracts have attracted interest in traditional medicine due to their beneficial health properties for reducing oxidative/inflammatory stress, which represents a critical component in cancer progression. However, other classes of natural compounds may have potential applications in the treatment or prevention of cancer. The identification of secondary metabolites from plants selected according to chemotaxonomic criteria, and the evaluation of their protective and therapeutic effects in cancer progression, are therefore of great interest.

As the circular economy is a new model that combines environmental, economic, and societal benefits, the choice of plants will not be limited to medicinal or food plants. It will focus on cultivated resources with high environmental potential, selected according to chemotaxonomic criteria.

This Special Issue will publish original research articles and reviews on aspects related to the antioxidant and anti-inflammatory properties of pure natural compounds and plant extracts with potential action in cancer treatment. They should be based on the characterization of the chemical profile of plant extracts combined with an in-depth biological evaluation that may explain or reveal the presence of a specific molecule or a family of molecules responsible for the observed activities.

Prof. Dr. Brigitte Deguin
Dr. Lorenza Trabalzini
Dr. Rosa Tundis
Guest Editors

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Keywords

  • phytochemical characterization
  • antioxidant and anti-inflammatory natural compounds and extracts
  • natural waste resources
  • horticultural or wild plants, medicinal plants, and edible plants
  • green selective extraction processes

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Published Papers (1 paper)

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38 pages, 10621 KiB  
Review
Telomerase Inhibition in the Treatment of Leukemia: A Comprehensive Review
by Elżbieta Bartoszewska, Klaudia Molik, Marta Woźniak and Anna Choromańska
Antioxidants 2024, 13(4), 427; https://doi.org/10.3390/antiox13040427 - 30 Mar 2024
Cited by 1 | Viewed by 2014
Abstract
Leukemia, characterized by the uncontrolled proliferation and differentiation blockage of myeloid or lymphoid precursor cells, presents significant therapeutic challenges despite current treatment modalities like chemotherapy and stem cell transplantation. Pursuing novel therapeutic strategies that selectively target leukemic cells is critical for improving patient [...] Read more.
Leukemia, characterized by the uncontrolled proliferation and differentiation blockage of myeloid or lymphoid precursor cells, presents significant therapeutic challenges despite current treatment modalities like chemotherapy and stem cell transplantation. Pursuing novel therapeutic strategies that selectively target leukemic cells is critical for improving patient outcomes. Natural products offer a promising avenue for developing effective chemotherapy and preventive measures against leukemia, providing a rich source of biologically active compounds. Telomerase, a key enzyme involved in chromosome stabilization and mainly active in cancer cells, presents an attractive target for intervention. In this review article, we focus on the anti-leukemic potential of natural substances, emphasizing vitamins (such as A, D, and E) and polyphenols (including curcumin and indole-3-carbinol), which, in combination with telomerase inhibition, demonstrate reduced cytotoxicity compared to conventional chemotherapies. We discuss the role of human telomerase reverse transcriptase (hTERT), particularly its mRNA expression, as a potential therapeutic target, highlighting the promise of natural compounds in leukemia treatment and prevention. Full article
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