Antioxidant Defenses in Fish—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (20 July 2024) | Viewed by 995

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Guest Editor
Major in Aquaculture and Applied Life Science, Division of Fisheries Life Sciences, College of Fisheries Sciences, Pukyong National University, Busan 48513, Republic of Korea
Interests: antioxidant defense; immune response; aquactic animal; disease prevention; aquaculture
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Special Issue Information

Dear Colleagues,

Fishes represent an extremely diverse group that exist in the most extreme and fluctuating aquatic environments through unique morphological, physiological, and biochemical adaptations. They, like other animals, have developed antioxidant defenses designed to counteract oxidative stress, including enzymatic or nonenzymatic, as well as being a system for repairing molecules. However, the modern culture system in fish tends to be more intensive and stressful, which can cause an imbalance between antioxidant defenses and the production of reactive oxygen species (ROS) that leads to adverse physiological and biochemical changes in fish.

Despite the extensive literature and research attempts regarding antioxidant machinery on biotic and abiotic factors, such as phylogenetic position, age, feeding behavior, environmental factors, presence of xenobiotics, etc., the data on the regulation of antioxidant defenses in fish are still limited at genetic and molecular levels. It is believed that a greater understanding of the genetic and molecular regulation of antioxidant defenses can provide a clue to restoring normal responses to oxidative damage in fish. 

This Special Issue will deal with reports that involve the latest research findings on molecular and genetic regulation of fish antioxidant defenses against oxidative stress in fish farming and also welcomes papers on the genomics, epigenomics, transcriptomics, and proteomics related to fish antioxidant defenses.

Prof. Dr. Chan-Hee Kim
Guest Editor

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Keywords

  • antioxidant defense
  • fish aquaculture
  • molecular and genetic regulation
  • genomics/epigenomics/transcriptomics/proteomics
  • biotic and abiotic factors
  • immune responses

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Published Papers (1 paper)

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Research

21 pages, 14131 KiB  
Article
Activation of Nrf2 at Critical Windows of Development Alters Tissue-Specific Protein S-Glutathionylation in the Zebrafish (Danio rerio) Embryo
by Emily S. Marques, Emily G. Severance, Paige Arsenault, Sarah M. Zahn and Alicia R. Timme-Laragy
Antioxidants 2024, 13(8), 1006; https://doi.org/10.3390/antiox13081006 - 19 Aug 2024
Viewed by 644
Abstract
Activation of Nrf2—the master regulator of antioxidative response—at different stages of embryonic development has been shown to result in changes in gene expression, but the tissue-specific and downstream effects of Nrf2 activation during development remain unclear. This work seeks to elucidate the tissue-specific [...] Read more.
Activation of Nrf2—the master regulator of antioxidative response—at different stages of embryonic development has been shown to result in changes in gene expression, but the tissue-specific and downstream effects of Nrf2 activation during development remain unclear. This work seeks to elucidate the tissue-specific Nrf2 cellular localization and the downstream changes in protein S-glutathionylation during critical windows of zebrafish (Danio rerio) development. Wild-type and mutant zebrafish embryos with a loss-of-function mutation in Nrf2a were treated with two canonical activators, sulforaphane (SFN; 40 µM) or tert-butylhydroquinone (tBHQ; 1 µM), for 6 h at either pharyngula, hatching, or the protruding-mouth stage. Nrf2a protein and S-glutathionylation were visualized in situ using immunohistochemistry. At the hatching stage, Nrf2a protein levels were decreased with SFN, but not tBHQ, exposure. Exposure to both activators, however, decreased downstream S-glutathionylation. Stage- and tissue-specific differences in Nrf2a protein and S-glutathionylation were identified in the pancreatic islet and liver. Protein S-glutathionylation in Nrf2a mutant fish was increased in the liver by both activators, but not the islets, indicating a tissue-specific and Nrf2a-dependent dysregulation. This work demonstrates that critical windows of exposure and Nrf2a activity may influence redox homeostasis and highlights the importance of considering tissue-specific outcomes and sensitivity in developmental redox biology. Full article
(This article belongs to the Special Issue Antioxidant Defenses in Fish—2nd Edition)
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