Dietary Antioxidants for Modulating the Aging Processes
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 91931
Special Issue Editors
Interests: brain aging; neurodegenerative diseases; food-based prevention; pharmacological intervention; mitochondrial function
Special Issues, Collections and Topics in MDPI journals
Interests: secondary plant compounds; neurodegenrative diseases; Alzheimers disease; proteostasis; mitophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The aging of the population is a global trend with dramatic implications for public health and the incidence of age-related diseases, including cardiovascular disease, diabetes mellitus type 2, and neurodegenerative diseases. In recent years, physical activity and dietary patterns, such as the "Mediterranean Diet", which is rich in polyphenols (PP), have become increasingly important in stimulating molecular mechanisms improving overall health. PP, such as resveratrol or protocatechuic acid, are known for their antioxidant, anti-inflammatory, anti-apoptotic, anticarcinogenic, and mitochondrial modulating properties and have therefore been frequently studied in relation to aging, mitochondrial function, and oxidative stress. Recent evidence suggests that classical antioxidants including PP and other plant-based compounds, such as carotenoids (xantophylls and carotenes) and vitamins (vitamin E and C) exert their protective effects through the induction of survival mechanisms similar to caloric restriction and physical activity, including the stimulation of longevity signals that go beyond direct antioxidant properties. Certain polyphenols of the human diet, including quercetin, are found in most plant sources, such as fruits and vegetables, while others, such as flavanones in citrus fruits or phloridzin in apples, are specific to a particular food. According to various reports, plant extracts containing a large number of the abovementioned substances could have the same or, based on synergistic effects, even a stronger health-promoting effect than their individual components. However, several intervention studies in humans have not been able to reproduce the positive effects observed in in vitro studies. The reasons for this are the low bioavailability and the extensive metabolism in vivo. The fact that PP are metabolized on a large scale in the body argues for the inclusion of metabolites in preclinical studies investigating molecular and cellular aspects of PP for biomedical questions. Therefore, those compounds have a great potential to influence human health through diet when the known obstacles, such as low concentrations, lack of bioavailability, and extensive metabolism, have been taken into account.
This Special Issue will cover topics linking the modulation of oxidative mechanisms by dietary antioxidants to physiological aging and age-related disorders. The research will not only enrich our understanding of how oxidative stress plays an important role in physiological aging and the initiation and of age-related diseases but will also provide evidence on antioxidant strategies for healthy aging in both experimental and clinical settings. Moreover, according to their general low concentrations in plasma, the effects of dietary antioxidants on gene expression have to be considered as an important mode of their action.
Topics of interest for this Special Issue include, but are not limited to, the following:
- Models of physiological aging and models of age-related diseases (excluding cancer!);
- Human studies including young and aged individuals;
- Clinical studies including patients with age-related diseases;
- Antioxidants that can be found in human diet (polyphenols, carotenes, vitamins, and co-enzymes);
- Single compounds and metabolites that can be identified in the human bloodstream. If complex mixtures or extracts are used, they should be analytically characterized and standardized to a valuable component.
Prof. Gunter Peter Eckert
Prof. Uwe Wenzel
Guest Editors
Manuscript Submission Information
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Keywords
- Aging
- Polyphenoles
- Oxidative Stress
- Mitochondria
- Mitophagy
- Proteostasis
- Metabolites
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