Oxidative Stress in Chronic Diseases: A Focus on Rheumatoid Arthritis

Dear Colleagues,

Reactive oxygen species (ROS) are products of cellular metabolism that, in controlled quantities, modulate several physiological aspects of cell function and are required for signaling pathways. Nonetheless, when excessive ROS production occurs or when their elimination by antioxidant mechanisms is impaired, they may accumulate and become pathogenic, a condition known as oxidative stress. Oxidative stress plays an important role in the development and exacerbation of several inflammatory, chronic, and autoimmune diseases. Recent advances in the understanding of the pathological action of oxidative species, as well as promising findings involving the prevention and even treatment of immunoinflammatory diseases with antioxidant therapies, have highlighted the potential of redox homeostasis for the maintenance of physiological functions and the prevention of numerous redox-dependent pathologies.

The aim of this Special Issue is to continue to explore the impact of ROS on cellular function, emphasizing the role of oxidative stress in inflammatory and autoimmune conditions. This Special Issue aims to present updated research on the relationship between oxidative stress and the development or exacerbation of chronic diseases, particularly inflammatory rheumatic disorders such as rheumatoid arthritis. This Special Issue will consider in vitro and in vivo studies investigating molecular mechanisms and the effects of antioxidant therapies on these conditions, highlighting the potential of maintaining redox homeostasis for preventing and managing redox-dependent pathologies. Both original and review articles are welcome.

Dr. Isaias Dichi
Dr. Alexandre Meira Pazelli
Dr. Bruna Miglioranza Scavuzzi
Guest Editors

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• rheumatic disorders
• autoimmune conditions
• oxidative stress
• inflammation
• redox state
• antioxidant therapy