Blood Cells and Redox Homeostasis in Health and Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (10 July 2024) | Viewed by 19202
Special Issue Editors
Interests: blood cells; hypoxia; metabolism; cancer metabolism; trauma; ageing; hemoglobinopathies; transfusion medicine; omics markers
Special Issues, Collections and Topics in MDPI journals
Interests: red blood cells; redox biology; red blood cell metabolism; storage lesion; extracellular vesicles; donor variation effect; transfusion medicine; hemoglobinopathies
Special Issue Information
Dear Colleague,
In several pathophysiological conditions, oxidative stress leads to the impairment of the functionality of blood cells and the emergence of oxidative markers. At the same time, the formed elements of blood are equipped with antioxidant systems and contribute to the balance of several molecules with antioxidant potential in plasma. Redox balance lies at the core of cellular and systems homeostasis and is maintained by a network of intertwined pathways, with a key cross-talk process between energy and redox metabolism, organelle biology, and proteostasis. The redox equilibrium is known to regulate and affect hematopoiesis, the immunometabolism of white blood cells, and red cell functions, among others; therefore, fluctuations in the blood cell redox status contribute to the etiopathology of several diseases, or represent early markers of pathological states. Understanding how oxidative stress impacts blood cell physiology and functionality is crucial to identify novel biomarkers and intervenable mechanisms for promising new therapies in many diseases. Moreover, several currently available iatrogenic and pharmacological interventions alter the oxidative status of blood cells, contributing to the complex puzzle of blood cells and redox homeostasis in health and disease.
This Special Issue aims to gather contributions that enhance our knowledge regarding the redox-related features of blood components and the impact of blood redox disequilibrium on pathophysiological backgrounds.
Potential topics include, but are not limited to, the following:
- Oxidative stress and hematopoiesis;
- Blood redox parameters in disease states;
- Oxidation and antioxidant systems in mitochondria-devoid, iron and oxygen-loaded red blood cells;
- Role of oxidative stress and redox systems in platelet activation and coagulopathy;
- Role of hypoxia in mitochondrial oxidant stress in the etiopathology of diseases;
- Role of iatrogenic (e.g., blood storage; extracorporeal membrane oxygenation) or other exposures (e.g., exercise, smoking, etc.) in oxidant stress generation and mitigation in blood cells;
- Effect of xenometabolites (including bacterial metabolites or drugs, e.g., common chemotherapeutic agents) on blood cell redox status;
- Redox therapies, including novel drug delivery systems;
- Role of aging and inflammation in blood cell oxidant stress.
Prof. Dr. Angelo D'Alessandro
Guest Editor
Dr. Alkmini T. Anastasiadi
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- blood
- redox status
- antioxidants
- oxidative stress
- redox therapy
- oxidative stress biomarkers
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