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Bioengineering
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Biomechanics Studies in Ophthalmology
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Biomechanics Studies in Ophthalmology

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomechanics and Sports Medicine".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 781

Special Issue Editor

Prof. Dr. Joseph L. Demer

E-Mail Website
Guest Editor
Departments of Ophthalmology, Neurology, and Bioengineering, and Stein Eye Institute, University of California, Los Angeles, CA, USA
Interests: biomechanics; eye movements; glaucoma; myopia; optic neuropathy; strabismus

Special Issue Information

Dear Colleagues,

Biomechanics can provide essential insights into the normal sensorimotor function of the eye and visual system, as well as the pathophysiology and treatment of important ocular diseases. This Special Issue welcomes submissions of reports on the mechanical properties and behavior of animal and human ocular tissues, computational models of organ-level behavior in the sensorimotor visual system in animals and humans, and mechanically based models providing insight into ocular diseases and their possible treatments.

Prof. Dr. Joseph L. Demer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • eye movements
  • finite element modeling
  • glaucoma
  • myopia
  • ocular biomechanics
  • ocular trauma
  • ocular viscoelasticity
  • optic neuropathy
  • strabismus

Published Papers (2 papers)

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Research

20 pages, 4815 KiB  
Article
Postmortem Digital Image Correlation and Finite Element Modeling Demonstrate Posterior Scleral Deformations during Optic Nerve Adduction Tethering
by Seongjin Lim, Changzoo Kim, Somaye Jafari, Joseph Park, Stephanie S. Garcia and Joseph L. Demer
Bioengineering 2024, 11(5), 452; https://doi.org/10.3390/bioengineering11050452 - 02 May 2024
Viewed by 263
Abstract
Postmortem human eyes were subjected to optic nerve (ON) traction in adduction and elevated intraocular pressure (IOP) to investigate scleral surface deformations. We incrementally adducted 11 eyes (age 74.1 ± 9.3 years, standard deviation) from 26° to 32° under normal IOP, during imaging [...] Read more.
Postmortem human eyes were subjected to optic nerve (ON) traction in adduction and elevated intraocular pressure (IOP) to investigate scleral surface deformations. We incrementally adducted 11 eyes (age 74.1 ± 9.3 years, standard deviation) from 26° to 32° under normal IOP, during imaging of the posterior globe, for analysis by three-dimensional digital image correlation (3D-DIC). In the same eyes, we performed uniaxial tensile testing in multiple regions of the sclera, ON, and ON sheath. Based on individual measurements, we analyzed eye-specific finite element models (FEMs) simulating adduction and IOP loading. Analysis of 3D-DIC showed that the nasal sclera up to 1 mm from the sheath border was significantly compressed during adduction. IOP elevation from 15 to 30 mmHg induced strains less than did adduction. Tensile testing demonstrated ON sheath stiffening above 3.4% strain, which was incorporated in FEMs of adduction tethering that was quantitatively consistent with changes in scleral deformation from 3D-DIC. Simulated IOP elevation to 30 mmHg did not induce scleral surface strains outside the ON sheath. ON tethering in incremental adduction from 26° to 32° compressed the nasal and stretched the temporal sclera adjacent to the ON sheath, more so than IOP elevation. The effect of ON tethering is influenced by strain stiffening of the ON sheath. Full article
(This article belongs to the Special Issue Biomechanics Studies in Ophthalmology)
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13 pages, 2004 KiB  
Article
Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study
by Marissé Masís Solano, Emmanuelle Richer, Santiago Costantino and Mark R. Lesk
Bioengineering 2024, 11(5), 411; https://doi.org/10.3390/bioengineering11050411 - 23 Apr 2024
Viewed by 355
Abstract
This study investigated the effect of intraocular pressure (IOP) reduction on pulsatile displacement within the optic nerve head (ONH) in primary open-angle glaucoma (POAG) patients with and without axial myopia. Forty-one POAG patients (19 without myopia, 9 with axial myopia and 13 glaucoma [...] Read more.
This study investigated the effect of intraocular pressure (IOP) reduction on pulsatile displacement within the optic nerve head (ONH) in primary open-angle glaucoma (POAG) patients with and without axial myopia. Forty-one POAG patients (19 without myopia, 9 with axial myopia and 13 glaucoma with no intervention) participated. Swept-source optical coherence tomography (OCT) videos of the ONH were obtained before and after IOP-lowering treatment (medical or surgical) achieving a minimum IOP drop of 3 mmHg. A demons registration-based algorithm measured local pulsatile displacement maps within the ONH. Results demonstrated a significant 14% decrease in pulsatile tissue displacement in the non-myopic glaucoma cohort after intervention (p = 0.03). However, glaucoma patients with axial myopia exhibited no statistically significant change. There were no significant changes in the pulsatile ONH deformation in the control group. These findings suggest a potential link between IOP reduction and reduced pulsatile displacement within the ONH in POAG patients without myopia, offering new insights into the disease’s pathophysiology and warranting further investigation into underlying mechanisms and clinical implications. Full article
(This article belongs to the Special Issue Biomechanics Studies in Ophthalmology)
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