Special Issue "Human Organs-on-Chips for In Vitro Disease Models"
A special issue of Bioengineering (ISSN 2306-5354).
Deadline for manuscript submissions: closed (31 May 2017)
The first generation of biomimetic microphysiological systems, so called “Human Organs-on-Chips”, has presented prodigious potential to reconstitute the 3D microarchitecture as well as the mechanical dynamics of human organs. In these engineered microsystem surrogate models, organ-level functions and in vivo relevant physiological responses have been recapitulated wherein the tissue-specific interactions may be in response to chemical (drugs, toxins, nutrients), physical (fluid shear stresses, mechanical deformations), or biological stimulations (microbiome, immune cells) and can be manipulated in a spatiotemporal manner.
With the breakthroughs of human organs-on-chips, the concept of “Biomimetic Reverse Engineering” that selects a minimal set of key pathophysiological factors has provided promising clues not only for the structural and functional reconstitution of human organs, but also for the modular recapitulation of a complex living system. For instance, by leveraging the microphysiological system, we can now decouple the complex pathophysiological factors contributing to diseases, then recouple the key interacting factors involved in the specific disease process.
Here, we envision that the next generation of the human organs-on-chips may rapidly validate the safety and efficacy of drug candidates, precisely dissect the complicated disease development, or faithfully assess the in vivo responses during clinical interventions. We may also contemplate to recruit human patient samples, integrate 3D organoid culture technology, replace synthetic materials with programmable biomaterials, rebuild sophisticated organ microarchitecture via 3D printing technology, or incorporate nanotechnology and bioelectronics-based sensing and detection modules in combination with the organs-on-chips.
We announce the Special Issue “Human Organs-on-Chips for In Vitro Disease Models” to come up with comprehensive understanding of the current state-of-the-art technologies in combination with the human microphysiological systems to emulate human diseases.
We look forward to receiving your contributions for this Special Issue.
Dr. Hyun Jung Kim
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) is waived for well-prepared manuscripts submitted to this issue. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Human organs-on-chips
- Microphysiological systems
- In vitro disease models
- Human microbiome
- Biomimetic/bioinspired microengineering
- 3D organoid cultures
- Nano-scale technology
- 3D printing technology
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: A biomimetic model of tumor-macrophage interactions
Authors: Hunter Joyce, Adán Rodriguez, Amy Brock
Affiliation: Department of Biomedical Engineering, The University of Texas at Austin
Abstract: Reciprocal signaling between tumor cells and their complex microenvironment is a critical determinant of disease progression. Here we develop a spheroid co-culture system to model the in vivo interaction of macrophage cells with mammary tumor cell populations. Analysis of mammary tumors derived from a progressive series of genetically-matched C3-SV40-TAg cancer cell lines revealed differential recruitment of macrophage. Cells derived from a metastatic tumors (C3-SV40-TAg M6C) recruited significantly fewer macrophage than tumor cells derived from a mammary carcinoma (C3-SV40-TAg M6) or from hyperplastic mammary tissue (C3-SV40-TAg M28). Conventional 2D co-culture of the same tumor cells with macrophage failed to mimic the differential recognition and engulfment of the cell line panel. However, co-culture in an alginate gel system revealed differential macrophage engulfment, mimicking the interactions observed in vivo.
Title: Tumor Microenvironment on Chip: The Progress and Future Perspective
Authors: Jungho Ahna,b,Yoshitaka Seia,e, Noo Li Jeonb and YongTae Kima,c,d,e
Affiliation: a George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA; b School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, 151-744, Korea; c Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Atlanta, GA, USA; d Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, Atlanta, GA, USA; e Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA
Abstract: Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The malignant or drug resistant nature of tumors relies on their environments, which become a promising therapeutic target for translational approaches. Microengineered systems mimicking tumor environments are one promising platform to allow quantitative and reproducible characterization of tumor responses in physiologically relevant conditions. This review highlights the recent advancements of microengineered tumor environment systems that enable unprecedented studies on cancer progression and metastasis. We also discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug screening applications.