Special Issue "New aspects of the Hepatocyte Growth Factor/c-Met System"
A special issue of Biomedicines (ISSN 2227-9059).
Deadline for manuscript submissions: closed (31 December 2014)
Prof. Dr. Maria Prat
This Special Issue, "New Insights on the Many Faces of the HGF/c-Met System", will mainly focus on the several roles exerted by the Hepatocyte Growth Factor (HGF) in development homeostasis (and related diseases).
The Hepatocyte Growth Factor/c- Met (HGF/c-Met) system has been extensively studied in the past two decades and has been shown to mediate multiple biological activities, such as cellular proliferation, survival, motility, morphogenesis, and angiogenesis. These pleiotropic and complex physiological functions act together during organogenesis and tissue homeostasis but can give rise to a broad spectrum of pathologies when the HGF/c-Met system physiological balance is disrupted. Knowledge of the HGF/c-Met physiological and pathological activities, and the elucidation of the pathways mediating them, have enabled the development of several promising “HGF-based” molecules with therapeutic effects. Examples of such molecules include HGF variants or fragments, HGF chimeras, and c-Met agonists/antagonists. Thus, newly available biotechnologies can help us address the challenges of preventing organ failure and contrasting cancer. We thus consider this subject to be of particular interest; the topic can expand biomedicine toward new horizons.
We invite authors to submit original research and review articles that focus on the biological functions and therapeutic potential of the HGF/c-Met system (or related molecules). Potential topics include, but are not limited to:
- HGF/c-Met system pathways;
- The biochemical characteristics of HGF and c-Met;
- The role of HGF in embryonic development and organogenesis;
- The role of HGF in tissue regeneration, homeostasis, and repair;
- HGF/c-Met in carcinogenesis;
- Recent advances in cancer therapies, based on interference with the HGF/c-Met system’s biological functions.
Dr. Giulia Ricci
Dr. Angela Catizone
Prof. Dr. Maria Prat
Dr. Stefania Scarpino
Dr. Rob Zachow
Dr. Zimmer Yitzhak
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.