Cancer-Related Signaling Cascades: Current Knowledge and Potential Therapeutic Targets
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 7918
Special Issue Editors
Interests: osteosarcoma; preclinical models of osteosarcoma; metastasis; tumor microenvironment; tumor immunology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer cells acquire the ability of infinite proliferation, and this ability ultimately leads to the death of individuals. ‘The hallmarks of cancer’ required for this fatal process have been clarified thus far; unlimited cell division, ligand-independent activation of growth signaling, resistance to anti-growth signals, apoptosis evasion, tissue invasion/metastasis, evasion from anti-tumor immune response, and enhancement of angiogenesis. These cancer hallmarks are attributable to the alterations of various intracellular signaling cascades caused by cell-intrinsic oncogenic mutations and microenvironmental stimuli. Therefore, altered cancer-associated signaling cascades have been utilized for the development of pharmacological cancer therapy.
Different cancer signaling cascades are altered based on cancer types and individual patients. Some cancers are addicted to a single cascade, and easily therapeutically targeted. In contrast, many other cancers are endowed with complex networks of altered cascades, and the determination of appropriate therapeutic targets is very difficult. Furthermore, crossover between multiple signaling cascades is a major cause of the resistance of the current targeted therapy.
To overcome this serious problem, this Special Issue offers an open access forum that aims to bring together a collection of original research and review articles addressing the expanding field of cancer-associated signaling cascades and their potential for cancer therapy.
We hope to provide a stimulating resource for the fascinating subject of cancer signaling cascades and their therapeutic implications.
Dr. Takatsune Shimizu
Dr. Hideyuki Takeshima
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer signaling
- crosstalk of signaling pathway
- oncogenic activation
- genetic alterations
- epigenetic alterations
- tumor microenvironment
- therapeutic resistance
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.