Perinatal Brain Injury—from Pathophysiology to Therapy
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 1065
Special Issue Editors
Interests: brain; child health; infection & immunity; regenerative medicine and stem cells
Interests: the basic development of microglia; innovative approaches in delayed chronic pharmacologic interventions; investigating the utility of a biocompatible hydrogel to regenerate neonatal stroke injury
Interests: perinatal neuroscience; oligodendrocytes; myelination deficits; neonatal hyperoxia; inflammation; hypoxia-Ischemia
Special Issue Information
Dear Colleagues,
A perinatal brain injury is a major risk factor for adverse neurodevelopmental outcomes and can trigger disturbed brain development with complex cellular and molecular alterations leading to long-term motor and cognitive deficits. The critical factors for adverse neurodevelopment include infection/inflammation, disturbed oxygenation (hyperoxia and hypoxia), blood flow (ischemia) hemorrhagic events and fetal malnutrition. Though our understanding of pathophysiological hallmarks has increased tremendously and standard care has improved markedly, interventions in the perinatal period to improve these neurological outcomes are still very limited. Therefore, there is still a need to improve our understanding of the underlying pathomechanisms in the developing brain, not only on a cellular level, but also in complex in vivo models. Basic scientific knowledge can be used to identify new therapeutic targets that will lead to treatments to improve the long-term outcomes and the quality of life of affected infants and their families.
This Special Issue aims to collect high-quality original manuscripts and reviews covering recent biomedical or clinical findings related to perinatal brain injuries, including new pharmacological or cell-based regenerative approaches to ameliorate the long-lasting deleterious consequences for brain development.
Dr. Cora H.A. Nijboer
Dr. Bobbi Fleiss
Dr. Ivo Bendix
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- preterm birth
- perinatal brain injury
- infection
- inflammation
- hypoxia
- ischemia
- hyperoxia
- malnutrition
- regenerative therapies
- pharmacological intervention
- stem cells
