Cellular Glycosphingolipids in Human Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 25 December 2024 | Viewed by 2122
Special Issue Editors
Interests: cellular glycosphingolipids; cancer; cancer health disparities
Special Issue Information
Dear Colleagues,
Within the mammalian plasma membrane, there is a large family of structurally and functionally diverse lipids called glycosphingolipids. These ubiquitous amphiphilic molecules include mono- and poly-glycosylated ceramides, including gangliosides, globosides, sulfatides, neolactosides, and others. Glycosphingolipids have been associated with a remarkable array of diverse biological processes, including cell growth, adhesion, differentiation, motility, which can significantly exacerbate cancer malignancy and are associated with poor outcomes. Glycosphingolipids are also known modulators of receptor tyrosine kinases and membrane embedded proteins, and are thus key players in the modulation of signal transduction pathways that can regulate cell growth and determine cell fate. In human cancers, they have been associated with increased proliferation, tumorigenesis, the epithelial-to-mesenchymal transition, metastasis, the development of chemoresistance, and responses to chemotherapy and immunotherapy. This special issue of Cells contains original research and review that further examines the roles that these lipids play in these and other critical processes in human cancers.
Dr. Santiago Lima
Dr. Amanda Dickinson
Guest Editors
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Keywords
- glycosphingolipid
- cancer
- sphingolipid
- signal transduction
- epithelial to mesenchymal
- ceramide
- microdomain
- chemoresistance
- glucosylceramide
- ganglioside
- globoside
- lactoside
- neolactoside
- sulfatide
- GSL
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