Macrophage Activation and Regulation
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 1069
Special Issue Editor
Special Issue Information
Dear Colleagues,
Activated macrophages are a critical component of host defence that provides frontline protection against pathogens and malignant cells; they are also a potent inducer and a key regulator of inflammation. Dysregulated macrophage activation contributes to a spectrum of diseases ranging from immunodeficiency inflammatory/immune-mediated to degenerative diseases. George Mackaness first coined the term “macrophage activation” to describe a state of enhanced microbicidal capacity in response to antigen-non-specific stimuli. Since then, the concept has continually evolved through multiple revisions and refinements. Nathan et al. showed that interferon-gamma is the key inducer of “classical activation”, soon followed by Gordon et al.’s discovery that IL-4/13 induces an alternative activation. Mantovani proposed the M1/M2 paradigm; a more flexible spectrum model is now preferred by many investigators, avoiding binary definitions. More recently, Netea et al. championed the concept of “trained immunity” as an antigen-non-specific innate immune memory.
Over the years, much has been learned about the pathways that induce or regulate macrophage activation and their role in homeostasis and diseases. This Special Issue of Cells aims to highlight the latest developments and cutting-edge research in this exciting and ever-evolving field of research. We invite submissions of original research articles and comprehensive reviews from investigators across the globe.
Dr. Subhankar Mukhopadhyay
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- macrophage activation
- classical and alternative activation
- M1 and M2 activation, inflammatory and regulatory cytokines
- inflammatory and pro-resolution lipid mediators
- immune activatory and inhibitory receptors
- ITAM and ITIMs
