Simple Organisms for Complex Problems: Modeling Human Disease in Yeast and Dictyostelium II
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2022
Special Issue Editor
Interests: autophagy; Dictyostelium; membrane trafficking
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The molecular pathways and mechanisms involved in human diseases are often conserved in simple eukaryotes. Microbial models, such as the yeast Saccharomyces cerevisiae and the social amoeba Dictyostelium discoideum, have traditionally been used in basic science to contribute to a better understanding of living organisms. Today, however, the boundaries of basic and applied science are blurring. Understanding the molecular mechanisms involved in diseases requires ever-deeper knowledge at the molecular level. In addition, the discovery of the underlying genetic cause of many rare diseases requires further investigation of the basic function of many as-yet poorly characterized genes, proteins and signaling pathways. Infectious diseases also benefit from the use of simple models to uncover the interaction between hosts and pathogens. In this complex scenario, the use of simple organisms as disease models is increasingly necessary to unravel intricate pathological mechanisms that could aid in the design of new knowledge-based therapies.
In this Special Issue we welcome contributions focused on the use of eukaryote microorganisms, such as Saccharomyces cerevisiae and Dictyostelium discoideum, to understand the molecular basis of human diseases.
Dr. Ricardo Escalante
Guest Editor
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Keywords
- Dictyostelium discoideum
- Saccharomyces cerevisiae
- human disease
- model organisms
