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Cells
Special Issues
Cell Biology: State-of-the-Art and Perspectives in China
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Cell Biology: State-of-the-Art and Perspectives in China

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 4635

Special Issue Editors

Prof. Dr. Di Chen

E-Mail Website
Guest Editor
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Research Center for Computer-aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Interests: osteoblast biology
Dr. Tong-Chuan He

E-Mail Website
Guest Editor
Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, USA
Interests: mesenchymal stem cells; bone and soft tissue tumors; BMP signaling; wnt signaling; cancer drug resistance; noncoding RNAs; bone and skeletal biology; cancer metastasis; regenerative medicine; gene therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleague,

This Special Issue aims to provide a comprehensive overview of the state-of-the-art of cell biology in China. We invite manuscripts that cover every aspect of cell biology. The Special Issue will publish full research articles and comprehensive reviews. Potential topics include but are not limited to the following research areas:

  • Cellular physiology:
  • Mesenchymal cell differentiation
  • Cell proliferation
  • Cell differentiation
  • Cell migration
  • Signal transduction
  • Signaling pathway interactions
  • Cell death regulation:
  • Apoptosis
  • Pyroptosis
  • Ferroptosis
  • Autophagy
  • Epigenetic regulation of cell function:
  • DNA methylation
  • Histone modification
  • Micro-RNA regulation
  • Ubiquitination
  • SUMOylation
  • Acetylation
  • OMICS:
  • Transcriptomics
  • Genomics
  • RNA-Seq
  • Proteomics
  • Glycomics
  • Lipidomics
  • Interactomics
  • Fluxomics
  • Biomics
  • Cell biology techniques:
  • CRISPR technique
  • Lineage tracing
  • Single cell RNA sequencing

Prof. Dr. Di Chen
Dr. Tong-Chuan He
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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20 pages, 8008 KiB  
Article
Integrated ATAC-seq and RNA-seq Analysis of In Vitro Cultured Skeletal Muscle Satellite Cells to Understand Changes in Cell Proliferation
by Zeyu Ren, Siyi Zhang, Liangyu Shi, Ao Zhou, Xin Lin, Jing Zhang, Xiusheng Zhu, Lei Huang and Kui Li
Cells 2024, 13(12), 1031; https://doi.org/10.3390/cells13121031 - 13 Jun 2024
Viewed by 1422
Abstract
Skeletal muscle satellite cells, the resident stem cells in pig skeletal muscle, undergo proliferation and differentiation to enable muscle tissue repair. The proliferative and differentiative abilities of these cells gradually decrease during in vitro cultivation as the cell passage number increases. Despite extensive [...] Read more.
Skeletal muscle satellite cells, the resident stem cells in pig skeletal muscle, undergo proliferation and differentiation to enable muscle tissue repair. The proliferative and differentiative abilities of these cells gradually decrease during in vitro cultivation as the cell passage number increases. Despite extensive research, the precise molecular mechanisms that regulate this process are not fully understood. To bridge this knowledge gap, we conducted transcriptomic analysis of skeletal muscle satellite cells during in vitro cultivation to quantify passage number-dependent changes in the expression of genes associated with proliferation. Additionally, we explored the relationships between gene transcriptional activity and chromatin accessibility using transposase-accessible chromatin sequencing. This revealed the closure of numerous open chromatin regions, which were primarily located in intergenic regions, as the cell passage number increased. Integrated analysis of the transcriptomic and epigenomic data demonstrated a weak correlation between gene transcriptional activity and chromatin openness in expressed genic regions; although some genes (e.g., GNB4 and FGD5) showed consistent relationships between gene expression and chromatin openness, a substantial number of differentially expressed genes had no clear association with chromatin openness in expressed genic regions. The p53-p21-RB signaling pathway may play a critical regulatory role in cell proliferation processes. The combined transcriptomic and epigenomic approach taken here provided key insights into changes in gene expression and chromatin openness during in vitro cultivation of skeletal muscle satellite cells. These findings enhance our understanding of the intricate mechanisms underlying the decline in cellular proliferation capacity in cultured cells. Full article
(This article belongs to the Special Issue Cell Biology: State-of-the-Art and Perspectives in China)
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19 pages, 6815 KiB  
Article
Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells
by Xie Xu, Kai He, Robert D. Hoffman, Yuyuan Ying, Nana Tao, Wenqin Guo, Jiaman Shen, Xi Liu, Meiya Li, Meiqiu Yan, Guiyuan Lv and Jianli Gao
Cells 2022, 11(22), 3679; https://doi.org/10.3390/cells11223679 - 19 Nov 2022
Cited by 6 | Viewed by 2109
Abstract
The thymus is the most sensitive organ under various pathophysiological conditions, such as aging, starvation, and infection. As a key stromal cell for T cell development, it is well-known that thymic epithelial cells (TECs) play an important role in the thymus response to [...] Read more.
The thymus is the most sensitive organ under various pathophysiological conditions, such as aging, starvation, and infection. As a key stromal cell for T cell development, it is well-known that thymic epithelial cells (TECs) play an important role in the thymus response to the external environment. Thymosin beta 15 (Tβ15) is a G-actin binding protein secreted by TECs, it plays an important role in maintaining the dynamic balance of actin, angiogenesis, axonal formation, and wound healing, but the relationship between Tβ15 and TECs is not clear yet. Here, we show the impact of Tβ15 on the TEC’s spatial development, as well as the T-cell differentiation and thymic output. As a result, TEC is the main effector cell of Tβ15 in the thymus. Tβ15 OX inhibits the chemotaxis of TECs to the medulla and subsequently blocks the positive selection of thymocytes from CD3+TCRβ+CD4+CD8+ double positive cells to CD3+TCRβ+CD4+CD8− single-positive (CD4SP) cells. Tβ15-knockdown accelerates the reticular differentiation of astral TECs and medullary TECs. Importantly, mice implanted with Tβ15-knockdown iTECs show high thymic output but low peripheral T cell maturity and activity. In a word, our results explain the role of Tβ15 on the differentiation and function of TECs and provide a new perspective for understanding the process of thymus development and degeneration. Full article
(This article belongs to the Special Issue Cell Biology: State-of-the-Art and Perspectives in China)
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